Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 12/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | UBE2N | P61088 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837475 | 0.91 | PTPN1 (0.40) | PTPN2PTPN1PTPRBCXCR2ALDH1A1 | |
| SCHEMBL6315778 | 0.87 | PTPN2 (0.38) | PTPN2PTPN1PTPRBCXCR2ALDH1A1 | |
| SCHEMBL5837700 | 0.85 | PTPN2 (0.41) | PTPN2PTPN1PTPRBCXCR2ALDH1A1 | |
| SCHEMBL5837130 | 0.82 | PTPN2 (0.35) | PTPN2PTPN1PTPRBCXCR2ALDH1A1 | |
| SCHEMBL5838672 | 0.82 | ADORA1 (0.38) | CXCR2ALDH1A1HPGDMAPTLMNA | |
| SCHEMBL5837100 | 0.80 | CXCR2 (0.36) | PTPN2PTPN1PTPRBCXCR2ALDH1A1 | |
| SCHEMBL5838122 | 0.78 | PTPN2 (0.39) | PTPN2PTPN1PTPRBCXCR2ALDH1A1 | |
| SCHEMBL5837892 | 0.77 | HPGD (0.43) | PTPN2PTPN1PTPRBALDH1A1HPGD | |
| SCHEMBL5838347 | 0.77 | GPR119 (0.39) | PTPN2PTPN1PTPRBCXCR2ALDH1A1 | |
| SCHEMBL5837704 | 0.77 | CXCR2 (0.39) | CXCR2ALDH1A1MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |