SCHEMBL5837627

SCHEMBL5837627

O=C1c2ccccc2C(=O)N1CC1CC2(CCN1)OCCO2

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.43
CYP2C19 P33261 3/20 0.43
CYP2C9 P11712 2/20 0.43
ALDH1A1 P00352 4/20 0.39
LMNA P02545 2/20 0.36
GAA P10253 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAP3K7 O43318 1/20 0.34
TAB1 Q15750 1/20 0.34
CDK5 Q00535 1/20 0.34
DYRK1A Q13627 1/20 0.34
CDK5R1 Q15078 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ACHE P22303 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5837668 0.99 CYP1A2 (0.42) CYP1A2CYP2C19CYP2C9ALDH1A1LMNA
SCHEMBL16282518 0.80 CYP1A2 (0.40) CYP1A2CYP2C19CYP2C9ALDH1A1LMNA
SCHEMBL16277757 0.80 CYP1A2 (0.40) CYP1A2CYP2C19CYP2C9ALDH1A1LMNA
SCHEMBL31023116 0.77 CYP1A2 (0.49) CYP1A2CYP2C19CYP2C9ALDH1A1LMNA
SCHEMBL7516886 0.75 ALDH1A1 (0.38) CYP1A2CYP2C19CYP2C9ALDH1A1LMNA
SCHEMBL21598055 0.74 CYP1A2 (0.51) CYP1A2CYP2C19CYP2C9ALDH1A1LMNA
SCHEMBL15672061 0.72 CYP1A2 (0.51) CYP1A2CYP2C19CYP2C9ALDH1A1MAP3K7
SCHEMBL14563296 0.72 CYP1A2 (0.51) CYP1A2CYP2C19CYP2C9ALDH1A1MAP3K7
SCHEMBL21564438 0.71 CYP1A2 (0.43) CYP1A2CYP2C19CYP2C9ALDH1A1ACHE
SCHEMBL14921361 0.71 CYP1A2 (0.50) CYP1A2CYP2C19CYP2C9MAP3K7TAB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7115624-B1 Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 NOVO NORDISK A/S (DK) 2006-10-03 US disclosed
EP-1214324-B1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) NOVO NORDISK AS (DK) 2006-06-14 EP disclosed
US-6410556-B1 ANTIDIABETIC AGENTS NOVO NORDISK A/S (DK) 2002-06-25 US disclosed
EP-1214060-A2 METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 NOVO NORDISK A/S (DK) 2002-06-19 EP disclosed
EP-1214324-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) NOVO NORDISK A/S (DK) 2002-06-19 EP disclosed
WO-2001019830-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) NOVO NORDISK A/S (DK) 2001-03-22 WO disclosed
WO-2001017516-A2 METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 NOVO NORDISK A/S (DK) 2001-03-15 WO disclosed