SCHEMBL5837982

SCHEMBL5837982

C=CC(=O)O[Si](CCCC)(C(C)C)C(C)C

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.46
HPGD P15428 1/20 0.46
THRB P10828 3/20 0.36
ZDHHC20 Q5W0Z9 1/20 0.36
ZDHHC2 Q9UIJ5 1/20 0.36
ALDH1A1 P00352 2/20 0.33
THRA P10827 1/20 0.33
CYP3A4 P08684 1/20 0.33
ATM Q13315 1/20 0.32
FAAH O00519 2/20 0.31
MAPT P10636 1/20 0.31
LMNA P02545 2/20 0.30
MEN1 O00255 1/20 0.30
MAPK1 P28482 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5838180 0.93 TSHR (0.43) TSHRHPGDTHRBZDHHC20ZDHHC2
SCHEMBL30073833 0.93 TSHR (0.43) TSHRHPGDTHRBZDHHC20ZDHHC2
SCHEMBL28469592 0.81 TSHR (0.44) TSHRHPGDALDH1A1CYP3A4MAPK1
SCHEMBL475947 0.80 LMNA (0.32) MAPTLMNA
SCHEMBL475948 0.78 ALDH1A1 (0.39) ALDH1A1FAAHMAPTLMNA
SCHEMBL21496183 0.78 TSHR (0.48) TSHRHPGDALDH1A1CYP3A4MAPK1
SCHEMBL5711146 0.78 TSHR (0.52) TSHRHPGDTHRBZDHHC20ZDHHC2
SCHEMBL2185379 0.77 TSHR (0.44) TSHRTHRBALDH1A1LMNA
SCHEMBL5838813 0.77 TSHR (0.50) TSHRHPGDTHRBZDHHC20ZDHHC2
SCHEMBL7179487 0.77 TSHR (0.50) TSHRHPGDTHRBZDHHC20ZDHHC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113444418-B Antifouling coating composition 中国涂料株式会社 2024-02-13 CN disclosed
CN-113444418-A Antifouling coating composition 中国涂料株式会社 2021-09-28 CN disclosed
US-20060276113-A1 Polishing cloth, polishing apparatus and method of manufacturing semiconductor devices HIRABAYASHI HIDEAKI 2006-12-07 US disclosed