SCHEMBL5838258

SCHEMBL5838258

C=CC(=O)OC(CC)[Si](C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 8/20 0.39
HPGD P15428 1/20 0.38
ALDH1A1 P00352 5/20 0.33
TP53 P04637 3/20 0.33
HIF1A Q16665 3/20 0.33
CYP3A4 P08684 2/20 0.33
HSD17B10 Q99714 1/20 0.33
THRB P10828 3/20 0.33
MAPK1 P28482 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10430815 0.85 TSHR (0.37) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL3746493 0.85 TSHR (0.37) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL9637778 0.85 TSHR (0.40) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL3738182 0.85 TSHR (0.37) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL18918481 0.85 TSHR (0.37) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL3738193 0.85 TSHR (0.37) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL3738205 0.85 TSHR (0.37) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL1603671 0.85 TSHR (0.37) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL11220689 0.84 TSHR (0.39) TSHRHPGDALDH1A1TP53HIF1A
SCHEMBL3482632 0.83 HCAR2 (0.39) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114402482-A Coated separator with fluoropolymer for lithium ion batteries 阿科玛股份有限公司 2022-04-26 CN claimed
US-11866531-B2 Oil-resistant lens material and ophthalmic devices Twenty Twenty Therapeutrics LLC (US) 2024-01-09 US disclosed
CN-114402482-A Coated separator with fluoropolymer for lithium ion batteries 阿科玛股份有限公司 2022-04-26 CN disclosed
CN-113429923-A Method of bonding hardware to vehicle glazing 3M创新有限公司 2021-09-24 CN disclosed
US-11045807-B2 Integrated platform for characterization of single cells or small cell clusters ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2021-06-29 US disclosed
EP-3234035-B1 RADIATION CURABLE COMPOSITION COMPRISING HYDROPHILIC NANOPARTICLES BASF COATINGS GMBH (DE) 2021-06-02 EP disclosed
WO-2021067189-A1 OIL-RESISTANT LENS MATERIAL AND ELECTROWETTING OPHTHALMIC DEVICES VERILY LIFE SCIENCES LLC (US) 2021-04-08 WO disclosed
US-20210095063-A1 OIL-RESISTANT LENS MATERIAL AND OPHTHALMIC DEVICES VERILY LIFE SCIENCES LLC 2021-04-01 US disclosed
CN-107109083-B Radiation curable compositions comprising hydrophilic nanoparticles 巴斯夫涂料有限公司 2021-01-08 CN disclosed
US-20200406253-A1 INTEGRATED PLATFORM FOR CHARACTERIZATION OF SINGLE CELLS OR SMALL CELL CLUSTERS ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2020-12-31 US disclosed
US-4898895-A Antifouling pain having a polyacrylate component with pendent silyl or siloxane groups NIPPON OIL AND FATS CO., LTD. (JP) 1990-02-06 US disclosed
US-4886864-A Silymethylene methacrylate contact lens and polymer JOHN D. MCCARRY (US) 1989-12-12 US disclosed
US-4883852-A SILICON CONTAINING ACRYLIC ESTER POLYMER, POLYSILOXANES NIPPON OIL AND FATS CO., LTD. (JP) 1989-11-28 US disclosed
EP-0316086-A2 Bracket for orthodontics and process for producing the same JAPAN INSTITUTE OF ADVANCED DENTISTRY (JP) 1989-05-17 EP disclosed
US-4814402-A VINYLPYRROLIDONE OR METHACRYLIC ACID AND SILICON CONTAINING METHACRYLATE MENICON CO., LTD. (JP) 1989-03-21 US disclosed
EP-0294515-A2 Contact lens material Menicon Co., Ltd. (JP) 1988-12-14 EP disclosed
US-4780516-A WETTABILITY; HARDNESS BIOMEDICS 1988-10-25 US disclosed
EP-0273457-A2 Antifouling paint NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1988-07-06 EP disclosed
US-4594401-A Oxygen permeable hard contact lens formed from styrene monomer containing a silyl or siloxane group SHIN-ETSU CHEMICAL CO., LTD. (JP) 1986-06-10 US disclosed
US-4433125-A COPOLYMER OF SILICON CONTAINING ACRYLATE OR METHACRYLATE, AND FLUOROALKYL ACRYLATE OR METHACRYLATE SHIN-ETSU CHEMICAL CO., LTD. (JP) 1984-02-21 US disclosed