Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 11/20 | 0.37 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837844 | 0.87 | HPGD (0.46) | HPGDHSD17B10FLT3RAB9ANPC1 | |
| SCHEMBL6315778 | 0.82 | PTPN2 (0.38) | HPGDSMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL5837475 | 0.78 | PTPN1 (0.40) | HPGDHSD17B10ALDH1A1TSHRKDM4E | |
| SCHEMBL5838593 | 0.77 | PTPN2 (0.39) | HPGDHSD17B10ALDH1A1KDM4EUSP2 | |
| SCHEMBL5837704 | 0.77 | CXCR2 (0.39) | HSD17B10ALDH1A1TSHRL3MBTL1KDM4E | |
| SCHEMBL5838347 | 0.76 | GPR119 (0.39) | HPGDHSD17B10SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5837100 | 0.75 | CXCR2 (0.36) | HPGDALDH1A1POLBPTPN2PTPN1 | |
| SCHEMBL5838097 | 0.74 | CTSS (0.45) | KMT2A | |
| SCHEMBL5838437 | 0.74 | CTSS (0.38) | PTPN2PTPN1PTPRB | |
| SCHEMBL7570664 | 0.73 | HPGD (0.50) | HPGDHSD17B10FLT3RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |