Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571109 | 0.78 | ALDH1A1 (0.39) | ALDH1A1ACHEKMT2ANPC1 | |
| SCHEMBL5838657 | 0.71 | ALDH1A1 (0.37) | TDP1ALDH1A1ATMLMNAACHE | |
| SCHEMBL5838696 | 0.71 | CXCR2 (0.42) | TDP1ALDH1A1ATMLMNAACHE | |
| SCHEMBL5838074 | 0.70 | GRM6 (0.39) | ALDH1A1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL14876479 | 0.69 | ATM (0.56) | TDP1ALDH1A1ATMLMNAACHE | |
| SCHEMBL5838338 | 0.69 | ALDH1A1 (0.32) | ALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL26744283 | 0.66 | ALDH1A1 (0.53) | TDP1ALDH1A1ATMLMNAACHE | |
| SCHEMBL4375792 | 0.64 | CA1 (0.59) | TDP1ALDH1A1ATMLMNAACHE | |
| SCHEMBL30050782 | 0.64 | CA1 (0.59) | TDP1ALDH1A1ATMLMNAACHE | |
| SCHEMBL11312416 | 0.62 | MEN1 (0.67) | TDP1ALDH1A1ATMLMNAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |