Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | DHODH | Q02127 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839695 | 0.90 | APEX1 (0.56) | SGMS2TP53HTTTDP1APEX1 | |
| SCHEMBL5839846 | 0.90 | HTT (0.63) | SGMS2TP53HTTAPEX1RAB9A | |
| SCHEMBL17253574 | 0.82 | RAB9A (0.52) | SGMS2HTTTDP1RAB9AALDH1A1 | |
| SCHEMBL5839896 | 0.81 | ALDH1A1 (0.54) | SGMS2TP53HTTTDP1APEX1 | |
| SCHEMBL5839388 | 0.81 | TP53 (0.68) | SGMS2TP53HTTALDH1A1CLCN2 | |
| SCHEMBL2446818 | 0.79 | APEX1 (0.57) | SGMS2TP53HTTTDP1APEX1 | |
| SCHEMBL5839915 | 0.78 | APEX1 (0.53) | TP53HTTAPEX1RAB9AALDH1A1 | |
| SCHEMBL6362198 | 0.78 | MAPT (0.65) | SGMS2HTTRAB9AALDH1A1NPC1 | |
| SCHEMBL2451525 | 0.78 | ALDH1A1 (0.68) | SGMS2TP53HTTALDH1A1NPC1 | |
| SCHEMBL1388155 | 0.78 | HTT (0.77) | SGMS2TP53HTTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984645-B2 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-01-10 | — | — | US | disclosed |