Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.56 |
| ▸ | TUBB | P07437 | 8/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.56 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.56 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.56 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.56 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.56 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.56 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.56 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841641 | 0.83 | TUBB1 (0.57) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5839514 | 0.81 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5841090 | 0.81 | TUBB1 (0.59) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5839375 | 0.76 | PAX8 (0.44) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5839385 | 0.76 | PAX8 (0.44) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5839653 | 0.76 | PAX8 (0.56) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL31238469 | 0.72 | TUBB4A (1.00) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5839934 | 0.72 | PAX8 (0.76) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL25492859 | 0.70 | TUBB1 (0.70) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1744686 | 0.70 | MAOA (0.50) | TSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135502-B1 | Colchinol derivatives as vascular damaging agents | ANGIOGENE PHARMACEUTICALS LTD. (GB) | 2006-11-14 | — | — | US | disclosed |
| US-20060128633-A1 | Colchinol derivatives as vascular damaging agents | ANGIOGENE PHARMACEUTICALS LTD. | 2006-06-15 | — | — | US | disclosed |
| EP-1140745-B1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | ANGIOGENE PHARM LTD (GB) | 2003-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128633-A1 | Colchinol derivatives as vascular damaging agents | NR1H3, NR1H2, NR1H4 | TUBB1 252/4885TUBB4A 1026/4885TUBB 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.