Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DHPS | P49366 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839987 | 0.96 | GRM5 (0.44) | GRM5KCNH2GRM2CYP1B1HRH3 | |
| SCHEMBL5838501 | 0.83 | CYP1B1 (0.51) | GRM5KCNH2GRM2CYP1B1CYP1A2 | |
| SCHEMBL5809501 | 0.81 | HTT (0.54) | HRH3HTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5810873 | 0.78 | HTT (0.43) | GRM5HRH3HTTALDH1A1LMNA | |
| SCHEMBL5812457 | 0.77 | DHPS (0.58) | GRM5HTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5839594 | 0.77 | GRM2 (0.49) | GRM5KCNH2GRM2CYP1B1HTT | |
| SCHEMBL5806592 | 0.76 | ALDH1A1 (0.49) | GRM5HRH3HTTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL16268410 | 0.76 | GRM5 (0.45) | GRM5KCNH2GRM2HTTALDH1A1 | |
| SCHEMBL5810628 | 0.75 | DRD2 (0.43) | GRM5HRH3HTTALDH1A1LMNA | |
| SCHEMBL5809369 | 0.73 | POLB (0.48) | GRM5HTTALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144894-B2 | Sulfonamide bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-05 | — | — | US | disclosed |
| US-20060063799-A1 | Sulfonamide bicyclic compounds | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063799-A1 | Sulfonamide bicyclic compounds | APP, BACE1, IAPP | GRM5 4093/4885KCNH2 2602/4885GRM2 4523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.