Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CDC25B | P30305 | 3/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.39 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840339 | 0.85 | BRAF (0.52) | MAPTALDH1A1SMN1; SMN2CDC25BCDC25A | |
| SCHEMBL5839549 | 0.80 | YTHDC1 (0.46) | CDC25BCDC25ACDC25C | |
| SCHEMBL4898607 | 0.80 | BRAF (0.61) | MAPTALDH1A1SMN1; SMN2CDC25BKMT2A | |
| SCHEMBL3007042 | 0.71 | BRAF (0.49) | MAPTALDH1A1CDC25BKMT2AMEN1 | |
| SCHEMBL1203237 | 0.70 | METTL3 (0.56) | MAPTALDH1A1SMN1; SMN2CDC25BCDC25A | |
| SCHEMBL1203877 | 0.70 | METTL3 (0.56) | MAPTALDH1A1SMN1; SMN2CDC25BCDC25A | |
| SCHEMBL17916012 | 0.70 | AURKA (0.47) | MAPTALDH1A1SMN1; SMN2CDC25BCDC25A | |
| SCHEMBL6578900 | 0.70 | MAPK1 (0.51) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29217168 | 0.70 | MAPT (0.57) | MAPTALDH1A1SMN1; SMN2CDC25BCDC25A | |
| SCHEMBL301182 | 0.69 | NPSR1 (0.47) | MAPTALDH1A1SMN1; SMN2CDC25BCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| EP-0874846-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997016452-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-05-09 | — | — | WO | disclosed |