Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 12/20 | 0.47 |
| ▸ | KCNJ11 | Q14654 | 12/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3870329 | 0.68 | GRIA1 (0.46) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL8473189 | 0.68 | ABCC8 (0.57) | ABCC8KCNJ11 | |
| SCHEMBL4256373 | 0.62 | ABCC8 (0.49) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL6792625 | 0.61 | ABCC8 (0.44) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL6208560 | 0.61 | ABCC8 (0.38) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL10542378 | 0.59 | RET (0.44) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL6798761 | 0.59 | ABCC8 (0.43) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL8286612 | 0.59 | ABCC8 (0.50) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL6997132 | 0.59 | ABCC8 (0.43) | ABCC8KCNJ11GRIA1GRIA2GRIA3 | |
| SCHEMBL13536240 | 0.57 | GRIA1 (0.45) | ABCC8KCNJ11GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | claimed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | claimed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | claimed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |