Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 12/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 12/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208560 | 0.71 | ABCC8 (0.38) | GRIA1GRIA2GRIA3GRIA4ABCC8 | |
| SCHEMBL5840885 | 0.69 | ABCC8 (0.44) | GRIA1GRIA2GRIA3GRIA4ABCC8 | |
| SCHEMBL13536240 | 0.68 | GRIA1 (0.45) | GRIA1GRIA2GRIA3GRIA4ABCC8 | |
| SCHEMBL5840892 | 0.68 | ABCC8 (0.47) | GRIA1GRIA2GRIA3GRIA4ABCC8 | |
| SCHEMBL8473189 | 0.68 | ABCC8 (0.57) | ABCC8KCNJ11CA2CA1CA12 | |
| SCHEMBL9267866 | 0.67 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4ABCC8 | |
| SCHEMBL5617424 | 0.65 | GRIA1 (0.49) | GRIA1GRIA2GRIA3GRIA4ABCC8 | |
| SCHEMBL3882804 | 0.64 | CA1 (0.41) | GRIA1GRIA2GRIA3GRIA4ABCC8 | |
| SCHEMBL6792625 | 0.64 | ABCC8 (0.44) | GRIA1GRIA2GRIA3GRIA4ABCC8 | |
| SCHEMBL9289749 | 0.64 | CA1 (0.44) | ABCC8KCNJ11CA2CA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476668-B2 | Thiadiazine derivatives and use thereof as positive AMPA receptor modulators | LES LABORATOIRES SERVIER (FR) | 2009-01-13 | — | — | US | disclosed |
| US-20070004709-A1 | Thiadiazine derivatives and use thereof as positive ampa receptor modulators | THE UNIVERSITE DE LIEGE (BE) | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004709-A1 | Thiadiazine derivatives and use thereof as positive ampa receptor modulators | GRM1, GRM3, GABRA1 | GRIA1 12/4885GRIA2 27/4885GRIA3 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.