Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.44 |
| ▸ | PTPRB | P23467 | 3/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 2/20 | 0.36 |
| ▸ | PTPRE | P23469 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837721 | 1.00 | PTPN1 (0.44) | PTPN1PTPN2PTPRBITGB1ITGA4 | |
| SCHEMBL7535354 | 0.86 | ITGA4 (0.40) | ITGB1ITGA4GRIA1ACECTSS | |
| SCHEMBL5838437 | 0.84 | CTSS (0.38) | PTPN1PTPN2PTPRBITGB1ITGA4 | |
| SCHEMBL5837778 | 0.82 | PTPN1 (0.52) | PTPN1PTPN2PTPRBPTPRCPTPRE | |
| SCHEMBL5838595 | 0.78 | CTSS (0.41) | ITGB1ITGA4GRIA1CTSSCTSK | |
| SCHEMBL5841058 | 0.78 | CTSS (0.41) | ITGB1ITGA4GRIA1CTSSCTSK | |
| SCHEMBL7119946 | 0.74 | PTPN1 (0.42) | PTPN1PTPN2PTPRBPTPRCPTPRE | |
| SCHEMBL5837241 | 0.74 | PTPN1 (0.46) | PTPN1PTPN2PTPRBPTPRCPTPRE | |
| SCHEMBL5837760 | 0.71 | PTPN1 (0.47) | PTPN1PTPN2PTPRB | |
| SCHEMBL7539431 | 0.69 | PTPN2 (0.39) | PTPN1PTPN2PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |