Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.33 |
| ▸ | NPY4R | P50391 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841058 | 1.00 | CTSS (0.41) | CTSSCTSKGRIA1ITGB1ITGA4 | |
| SCHEMBL5838437 | 0.88 | CTSS (0.38) | CTSSCTSKGRIA1ITGB1ITGA4 | |
| SCHEMBL5841164 | 0.87 | ADORA1 (0.49) | CTSSCTSKADORA1 | |
| SCHEMBL5837074 | 0.87 | ADORA1 (0.49) | CTSSCTSKADORA1 | |
| SCHEMBL5838379 | 0.82 | CTSS (0.32) | CTSSCTSKADORA1 | |
| SCHEMBL5841311 | 0.82 | CTSS (0.32) | CTSSCTSKADORA1 | |
| SCHEMBL6317021 | 0.81 | ADORA1 (0.35) | ADORA1 | |
| SCHEMBL5837721 | 0.78 | PTPN1 (0.44) | CTSSCTSKGRIA1ITGB1ITGA4 | |
| SCHEMBL5842848 | 0.78 | PTPN1 (0.44) | CTSSCTSKGRIA1ITGB1ITGA4 | |
| SCHEMBL5841350 | 0.78 | ADORA1 (0.34) | ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |