Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | CTSS | P25774 | 19/20 | 0.48 |
| ▸ | CTSL | P07711 | 17/20 | 0.48 |
| ▸ | CTSK | P43235 | 17/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842968 | 0.84 | CTSS (0.68) | ABL1KCNH2CTSSCTSLCTSK | |
| SCHEMBL5842964 | 0.84 | CTSS (0.68) | ABL1KCNH2CTSSCTSLCTSK | |
| SCHEMBL5843012 | 0.80 | CTSS (0.48) | CTSSCTSLCTSK | |
| SCHEMBL5843533 | 0.79 | CTSS (0.56) | CTSSCTSLCTSK | |
| SCHEMBL5844528 | 0.78 | CTSS (0.53) | CTSSCTSLCTSK | |
| SCHEMBL5844353 | 0.77 | CTSS (0.55) | CTSSCTSLCTSK | |
| SCHEMBL5842433 | 0.76 | CTSS (0.62) | CTSSCTSLCTSK | |
| SCHEMBL5842534 | 0.75 | CTSS (0.57) | CTSSCTSLCTSK | |
| SCHEMBL5844153 | 0.74 | CTSS (0.54) | CTSSCTSLCTSK | |
| SCHEMBL5844379 | 0.74 | CTSS (0.57) | CTSSCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | claimed |
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | disclosed |
| WO-2004084842-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |
| US-20040198780-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198780-A1 | Inhibitors of cathepsin S | CTSS, CTSK, CTSE | ABL1 1823/4885KCNH2 3243/4885CTSS 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.