Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27896435 | 1.00 | KEAP1 (0.52) | KEAP1NFE2L2LMNAMAPK1PSMB5 | |
| SCHEMBL5843204 | 1.00 | KEAP1 (0.52) | KEAP1NFE2L2LMNAMAPK1PSMB5 | |
| SCHEMBL15743807 | 0.84 | KEAP1 (0.54) | KEAP1NFE2L2LMNAMAPK1PSMB5 | |
| SCHEMBL8584122 | 0.84 | CTSD (0.56) | LMNAMMEMEN1KMT2A | |
| SCHEMBL8584123 | 0.84 | CTSD (0.56) | LMNAMMEMEN1KMT2A | |
| SCHEMBL197183 | 0.82 | KEAP1 (0.58) | KEAP1NFE2L2LMNAMAPK1PSMB5 | |
| SCHEMBL197182 | 0.82 | KEAP1 (0.58) | KEAP1NFE2L2LMNAMAPK1PSMB5 | |
| SCHEMBL28408400 | 0.80 | MEN1 (0.64) | KEAP1NFE2L2LMNAMAPK1HPGD | |
| SCHEMBL8974575 | 0.80 | MEN1 (0.64) | KEAP1NFE2L2LMNAMAPK1HPGD | |
| SCHEMBL19119737 | 0.80 | KEAP1 (0.50) | KEAP1NFE2L2LMNAMAPK1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102791693-A | Hepatitis c virus inhibitors | BRISTOL MYERS SQUIBB CO | 2012-11-21 | — | — | CN | claimed |
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | claimed |