Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.47 |
| ▸ | TLR2 | O60603 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27677788 | 0.88 | KMT2A (0.54) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL31675022 | 0.88 | MDM4 (0.60) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL29401430 | 0.88 | MDM4 (0.60) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL30353997 | 0.88 | MDM4 (0.60) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL10187006 | 0.88 | KMT2A (0.52) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL178787 | 0.88 | MDM4 (0.60) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL118051 | 0.88 | MDM4 (0.60) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL12677657 | 0.88 | KMT2A (0.52) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL29378420 | 0.88 | MDM4 (0.60) | MDM4TP53CASP3KMT2AMDM2 | |
| SCHEMBL30191581 | 0.88 | MDM4 (0.60) | MDM4TP53CASP3KMT2AMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | disclosed |
| WO-2004084842-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |
| US-20040198780-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198780-A1 | Inhibitors of cathepsin S | CTSS, CTSK, CTSE | MDM4 4690/4885TP53 1192/4885CASP3 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.