Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845661 | 0.90 | CRHR1 (0.41) | LMNAGAACRHR1 | |
| SCHEMBL27584914 | 0.83 | FFAR2 (0.31) | CRHR1 | |
| SCHEMBL5844195 | 0.81 | CRHR1 (0.49) | LMNAGAACRHR1 | |
| SCHEMBL5843491 | 0.81 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL5843602 | 0.81 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL5844423 | 0.81 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5842985 | 0.81 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5843917 | 0.80 | CRHR1 (0.58) | LMNAGAACRHR1 | |
| SCHEMBL5842869 | 0.79 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL5843931 | 0.78 | CRHR1 (0.38) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590158-B2 | Total synthesis of shishijimicin A and analogs thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2020-03-17 | — | — | US | disclosed |
| US-20180327439-A1 | TOTAL SYNTHESIS OF SHISHIJIMICIN A AND ANALOGS THEREOF | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-11-15 | — | — | US | disclosed |
| US-7125880-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-7067664-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-06-27 | — | — | US | disclosed |
| EP-0967217-B1 | Reagents and methods for solid phase synthesis and display | AFFYMETRIX INC (US) | 2005-12-21 | — | — | EP | disclosed |
| US-6956047-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-20050032846-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2005-02-10 | — | — | US | disclosed |
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| US-6833378-B2 | Pyridines, pyrimidines, purinones, pyrrolopyrimidinones and pyrrolopyridinones; useful in the treatment disorders including CNS and stress-related disorders. | PFIZER INC | 2004-12-21 | — | — | US | disclosed |
| EP-1263732-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2002-12-11 | — | — | EP | disclosed |
| US-20020016328-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2002-02-07 | — | — | US | disclosed |
| WO-2001053263-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2001-07-26 | — | — | WO | disclosed |
| EP-0363589-A2 | Somatostatin analogues | SYNTEX (U.S.A.) INC. (US) | 1990-04-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590158-B2 | Total synthesis of shishijimicin A and analogs thereof | SYK, UGT1A7, FCGRT | LMNA 4587/4885GAA 515/4885CRHR1 4433/4885 |
| US-20180327439-A1 | TOTAL SYNTHESIS OF SHISHIJIMICIN A AND ANALOGS THEREOF | SYK, UGT1A7, FCGRT | LMNA 4587/4885GAA 515/4885CRHR1 4433/4885 |
| US-20020016328-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | LMNA 4189/4885GAA 2029/4885CRHR1 3/4885 |
| US-20050032846-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | LMNA 4152/4885GAA 1321/4885CRHR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.