Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844195 | 0.91 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL5845758 | 0.89 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL6797656 | 0.86 | HPGD (0.47) | ALDH1A1MAPK1SMN1; SMN2CRHR1 | |
| SCHEMBL5844550 | 0.82 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL5844403 | 0.82 | HPGD (0.44) | ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL5845333 | 0.81 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL27489799 | 0.81 | CRHR1 (0.36) | CRHR1 | |
| SCHEMBL5843964 | 0.79 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6792213 | 0.79 | CRHR1 (0.44) | MAPK1SMN1; SMN2CRHR1 | |
| SCHEMBL5844170 | 0.78 | CRHR1 (0.46) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125880-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-7067664-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-6956047-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-20050032846-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2005-02-10 | — | — | US | disclosed |
| US-6833378-B2 | Pyridines, pyrimidines, purinones, pyrrolopyrimidinones and pyrrolopyridinones; useful in the treatment disorders including CNS and stress-related disorders. | PFIZER INC | 2004-12-21 | — | — | US | disclosed |
| CN-1395566-A | Corticotropin releasing factor antagonists | PFIZER PROD INC (US) | 2003-02-05 | — | — | CN | disclosed |
| US-20020016328-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2002-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016328-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | ALDH1A1 4505/4885MAPK1 1208/4885SMN1; SMN2 1860/4885 |
| US-20050032846-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | ALDH1A1 4423/4885MAPK1 3258/4885SMN1; SMN2 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.