Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844195 | 0.90 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL5843964 | 0.87 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5844170 | 0.86 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5600278 | 0.84 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL5844988 | 0.82 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5787105 | 0.82 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5845661 | 0.82 | CRHR1 (0.41) | CRHR1MEN1KMT2A | |
| SCHEMBL5845758 | 0.81 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL5844815 | 0.81 | ALDH1A1 (0.41) | CRHR1 | |
| SCHEMBL5844111 | 0.81 | CRHR1 (0.41) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125880-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-7067664-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-6956047-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-20050118164-A1 | Targeted ligands | HERMAN WILLIAM (CA) | 2005-06-02 | — | — | US | disclosed |
| US-6875769-B2 | Substituted6,6-hetero-bicyclicderivatives | PFIZER INC. (US) | 2005-04-05 | — | — | US | disclosed |
| US-20050032846-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2005-02-10 | — | — | US | disclosed |
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| US-6833378-B2 | Pyridines, pyrimidines, purinones, pyrrolopyrimidinones and pyrrolopyridinones; useful in the treatment disorders including CNS and stress-related disorders. | PFIZER INC | 2004-12-21 | — | — | US | disclosed |
| EP-0925298-B1 | SUBSTITUTED 6,6-HETERO-BICYCLIC DERIVATIVES | PFIZER (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20030114671-A1 | Substituted6,6-hetero-bicyclicderivatives | CHEN YUHPYNG L (US) | 2003-06-19 | — | — | US | disclosed |
| EP-1263732-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2002-12-11 | — | — | EP | disclosed |
| US-20020016328-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2002-02-07 | — | — | US | disclosed |
| WO-2001053263-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2001-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020016328-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | CRHR1 3/4885HSD17B10 2002/4885MEN1 1835/4885 |
| US-20030114671-A1 | Substituted6,6-hetero-bicyclicderivatives | CYP2D6, CYP2B6, CYP2A6 | CRHR1 2119/4885HSD17B10 533/4885MEN1 1562/4885 |
| US-20050032846-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | CRHR1 3/4885HSD17B10 1489/4885MEN1 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.