Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511463 | 0.96 | CYP3A4 (0.45) | CYP3A4CYP2D6CYP2C9LIPGTLR8 | |
| Hydrochloric Acid SCHEMBL11294295 | 0.95 | CYP3A4 (0.44) | CYP3A4CYP2D6CYP2C9LIPGTLR8 | |
| SCHEMBL1078217 | 0.91 | LIPG (0.51) | CYP3A4CYP2D6CYP2C9LIPGTLR8 | |
| SCHEMBL27813777 | 0.90 | LIPG (0.54) | CYP3A4LIPGKMT2AMEN1NR1I2 | |
| SCHEMBL10619679 | 0.90 | LIPG (0.54) | CYP3A4LIPGKMT2AMEN1NR1I2 | |
| SCHEMBL10804965 | 0.85 | KMT2A (0.39) | LIPGKMT2ALMNAHTTALDH1A1 | |
| Water SCHEMBL28035664 | 0.84 | KMT2A (0.38) | LIPGKMT2ALMNAHTTALDH1A1 | |
| SCHEMBL6685696 | 0.81 | CYP3A4 (0.42) | CYP3A4CYP2D6CYP2C9LIPGTLR8 | |
| SCHEMBL29732173 | 0.81 | F2 (0.42) | KMT2ALMNAHTTALDH1A1 | |
| SCHEMBL1002853 | 0.79 | MAPT (0.53) | CYP3A4LIPGKMT2AMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141687-B2 | N'-substituted N-acylamidine metal transition complexes and their use as catalysts | BASF AKTIENGESELLSCHAFT (DE) | 2006-11-28 | — | — | US | disclosed |
| US-20060069275-A1 | N'-substituded n-acylamidine metal transition complexes and their use as catalysts | BASF AKTIENGESELLSCHAFT (DE) | 2006-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069275-A1 | N'-substituded n-acylamidine metal transition complexes and their use as catalysts | NR1I3, NR0B1, NR4A1 | CHRM2 1127/4885SLC6A3 756/4885CYP3A4 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.