Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 6/20 | 0.97 |
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 0.97 |
| ▸ | MAPT | P10636 | 5/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.97 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | RECQL | P46063 | 1/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | HPGD | P15428 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.97 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.97 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.97 |
| ▸ | THPO | P40225 | 1/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.97 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexketoprofen SCHEMBL29396875 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Dexketoprofen SCHEMBL66987 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8754790 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL16757741 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL679920 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL8577572 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL29353694 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL3843886 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| R-Ketoprofen SCHEMBL195303 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 | |
| Ketoprofen SCHEMBL2896 | 0.98 | PTGS1 (1.00) | PTGS1PTGS2MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111249801-A | Decarburizing and filtering device and method for preparing aminolevulinic acid hydrochloride | 上海万巷制药有限公司 | 2020-06-09 | — | — | CN | claimed |
| CN-1625411-A | Combination of a NSAID and a PDE-4 inhibitor | ALTANA PHARMA AG (DE) | 2005-06-08 | — | — | CN | claimed |
| CN-115671059-A | Freeze-dried preparation of aminolevulinic acid hydrochloride and preparation method thereof | 兆科药业（合肥）有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115671059-A | Freeze-dried preparation of aminolevulinic acid hydrochloride and preparation method thereof | 兆科药业（合肥）有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115671031-A | Temperature-sensitive transdermal absorption enhancer | 山东正肤奇生物科技有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115501338-A | Preparation method of temperature-sensitive microgel carrying aminolevulinic acid hydrochloride | 浙江蓝禾医疗用品有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-115038432-A | Controlled release granulation of water soluble active pharmaceutical ingredients | 凯瑞康宁生物工程（武汉）有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-111249801-B | Decarburizing and filtering device and method for preparing aminolevulinic acid hydrochloride | 上海万巷制药有限公司 | 2021-10-01 | — | — | CN | disclosed |
| CN-112585690-A | System and method for producing individualized individual unit doses containing a pharmaceutically active substance | 阿奎斯蒂弗医疗股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-211584866-U | Stirring medicine coating kit | 武汉市第一医院 | 2020-09-29 | — | — | CN | disclosed |
| CN-111249801-A | Decarburizing and filtering device and method for preparing aminolevulinic acid hydrochloride | 上海万巷制药有限公司 | 2020-06-09 | — | — | CN | disclosed |
| US-20130123320-A1 | TOPICAL COMPOSITION FOR PAIN RELIEF | CHERVINSKY ALEX (US) | 2013-05-16 | — | — | US | disclosed |
| WO-2012159962-A1 | PHARMACEUTICAL COMPOSITION COMPRISING KETOPROFEN | AVENTIS PHARMA S.A. (FR) | 2012-11-29 | — | — | WO | disclosed |
| CN-100496607-C | Combination of a NSAID and a PDE-4 inhibitor | ALTANA PHARMA AG (DE) | 2009-06-10 | — | — | CN | disclosed |
| US-7012138-B1 | Chiral polysaccharide esters, one of the methods for preparing them and their uses for obtaining optically enriched acids or for chiral chromatography | UNIVERSITE DE DROIT D'ECONOMIE ET DES SCIENCES D'AIZ-MARSEILLE (FR) | 2006-03-14 | — | — | US | disclosed |
| CN-1625411-A | Combination of a NSAID and a PDE-4 inhibitor | ALTANA PHARMA AG (DE) | 2005-06-08 | — | — | CN | disclosed |
| EP-0759899-B1 | NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES | NICOX SA (FR) | 1999-09-15 | — | — | EP | disclosed |
| US-5861426-A | NITRO ESTERS OF AROMATIC COMPOUNDS WITH AMIDE OR ESTER GROUPS | NICOX S.A. (FR) | 1999-01-19 | — | — | US | disclosed |
| EP-0759899-A1 | NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES | NICOX S.A. (FR) | 1997-03-05 | — | — | EP | disclosed |
| WO-1995030641-A1 | NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES | NICOX S.A. (FR) | 1995-11-16 | — | — | WO | disclosed |