Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 11/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | CCR1 | P32246 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159869 | 0.93 | CCR1 (0.50) | CCR3DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL5847174 | 0.91 | DRD2 (0.57) | DRD2HTR1AHTR2ADRD3DRD4 | |
| SCHEMBL5848271 | 0.91 | SIGMAR1 (0.53) | CCR3DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL5846506 | 0.82 | DRD2 (0.50) | CCR3DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL5848902 | 0.80 | OPRL1 (0.54) | DRD2HTR1AHTR2ADRD3DRD4 | |
| SCHEMBL11938907 | 0.77 | DRD2 (0.65) | CCR3DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL14307260 | 0.76 | CCR3 (0.69) | CCR3DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL10287607 | 0.75 | OPRM1 (0.63) | CCR3DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL1132636 | 0.74 | CCR1 (0.65) | CCR3DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL10610496 | 0.74 | DRD2 (0.65) | CCR3DRD2HTR1AHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39113-E1 | Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2006-05-30 | — | — | US | claimed |
| EP-0721455-B9 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2005-04-20 | — | — | EP | claimed |
| EP-1097698-B1 | UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN | ESTEVE LABOR DR (ES) | 2003-05-07 | — | — | EP | claimed |
| EP-0721455-B1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2002-12-11 | — | — | EP | claimed |
| EP-1097698-A2 | UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-05-09 | — | — | EP | claimed |
| EP-0721455-A1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1996-07-17 | — | — | EP | claimed |
| WO-1996004287-A1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1996-02-15 | — | — | WO | claimed |