Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.45 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PLEC | Q15149 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 3/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27695223 | 0.91 | PTGER4 (0.45) | PTGER4LIPCLIPGKDM4EALDH1A1 | |
| SCHEMBL4230564 | 0.86 | PTGER4 (0.48) | PTGER4LIPCLIPGKDM4CKDM4E | |
| SCHEMBL585072 | 0.84 | PTGER4 (0.46) | PTGER4LIPCLIPGKDM4CKDM4E | |
| SCHEMBL584692 | 0.83 | ALDH1A1 (0.44) | PTGER4ALDH1A1MAPTHTT | |
| SCHEMBL584693 | 0.83 | ALDH1A1 (0.44) | PTGER4ALDH1A1MAPTHTT | |
| SCHEMBL4968421 | 0.80 | NR1H3 (0.41) | PTGER4ALDH1A1HPGDHTT | |
| SCHEMBL3923613 | 0.78 | PTGER4 (0.47) | PTGER4LIPCLIPGKDM4CKDM4E | |
| SCHEMBL4967122 | 0.78 | PTGER4 (0.49) | PTGER4LIPCLIPGKDM4CKDM4E | |
| SCHEMBL3765728 | 0.77 | PTGER4 (0.64) | PTGER4KDM4EALDH1A1GAAMAPT | |
| SCHEMBL584850 | 0.77 | PTGER4 (0.46) | PTGER4LIPCLIPGALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797077-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF I | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |