Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.38 |
| ▸ | KDM6B | O15054 | 2/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | PLEC | Q15149 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584616 | 0.91 | PTGER4 (0.46) | PTGER4RORCCREBBPKDM4CKDM6B | |
| Hydrochloric Acid SCHEMBL3917055 | 0.90 | PTGER4 (0.46) | PTGER4RORCCREBBPKDM4CKDM6B | |
| SCHEMBL4230564 | 0.88 | PTGER4 (0.48) | PTGER4CREBBPKDM4CLIPCLIPG | |
| SCHEMBL584659 | 0.84 | PTGER4 (0.45) | PTGER4KDM4CLIPCLIPGKDM4E | |
| SCHEMBL585142 | 0.83 | HCAR3 (0.47) | KDM4EALDH1A1MAPTHPGDHTT | |
| SCHEMBL585141 | 0.83 | HCAR3 (0.47) | KDM4EALDH1A1MAPTHPGDHTT | |
| SCHEMBL4966217 | 0.82 | PTGER4 (0.47) | PTGER4RORCCREBBPKDM4CKDM6B | |
| SCHEMBL5434827 | 0.81 | ALDH1A1 (0.38) | PTGER4KDM4CKDM6BKDM4EALDH1A1 | |
| SCHEMBL4967122 | 0.80 | PTGER4 (0.49) | PTGER4CREBBPKDM4CCNR2LIPC | |
| SCHEMBL4967688 | 0.79 | RORC (0.45) | PTGER4RORCCREBBPKCNH3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797077-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF I | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| US-20070072853-A1 | Benzimidazole derivatives compositions containing them, preparation thereof and uses thereof | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072853-A1 | Benzimidazole derivatives compositions containing them, preparation thereof and uses thereof | RB1, CYP2C19, ADRB3 | PTGER4 46/4885RORC 1350/4885CREBBP 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.