Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CCR6 | P51684 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | S100A4 | P26447 | 2/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5707613 | 0.84 | ALDH1A1 (0.54) | LMNACA2CA9ALDH1A1HTT | |
| SCHEMBL28752524 | 0.84 | ALDH1A1 (0.51) | LMNACA2CA9ESR1ESR2 | |
| SCHEMBL28752521 | 0.84 | LMNA (0.56) | LMNACA2CA9ESR1ESR2 | |
| SCHEMBL9806781 | 0.83 | LMNA (0.81) | LMNACA2CA9ALDH1A1POLB | |
| SCHEMBL19380491 | 0.82 | LMNA (0.71) | LMNACA2CA9SCN2AALDH1A1 | |
| SCHEMBL6857955 | 0.82 | LMNA (0.51) | LMNACA2CA9ESR1ESR2 | |
| SCHEMBL11305617 | 0.80 | ESR1 (0.57) | LMNACA2CA9SCN2AESR1 | |
| SCHEMBL16655162 | 0.80 | ESR1 (0.57) | LMNACA2CA9SCN2AESR1 | |
| SCHEMBL2891199 | 0.80 | ATM (0.49) | LMNACA2CA9SCN2AESR1 | |
| SCHEMBL11863055 | 0.80 | ESR1 (0.57) | LMNASCN2AESR1ESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5078351-A | — | — | None | — | — | JP | disclosed |
| US-7151112-B1 | Pharmaceutical uses and synthesis of nicotinamides | UCB SA (GB) | 2006-12-19 | — | — | US | disclosed |
| US-6777432-B1 | TREATING A SUBJECT HAVING AN INFLAMMATORY DISORDER ALLEVIATED BY THE INHIBITION OF GRO- ALPHA CYTOKINES | DARWIN MOLECULAR CORPORATION | 2004-08-17 | — | — | US | disclosed |
| JP-H0578351-A | TETRAHYDROPHTHALIMIDE DERIVATIVE | SUMITOMO CHEM CO LTD | 1993-03-30 | — | — | JP | disclosed |
| EP-0322401-B1 | TETRAHYDROPHTHALIMIDE DERIVATIVES, THEIR PRODUCTION AND USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1992-07-08 | — | — | EP | disclosed |
| US-3966726-A | Process for the production of cyclic carboxylic acid imides | AKZO N.V. (NL) | 1976-06-29 | — | — | US | disclosed |
| JP-H00578351-A | — | — | 0001-01-01 | — | — | JP | disclosed |