Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846134 | 0.85 | ELANE (0.41) | ELANE | |
| SCHEMBL5846685 | 0.77 | ALDH1A1 (0.42) | CYP1A2CYP2D6CYP3A4KMT2AHSD17B10 | |
| SCHEMBL5760136 | 0.75 | ROCK2 (0.51) | LMNA | |
| SCHEMBL5762196 | 0.73 | CHRNA7 (0.39) | ELANECYP3A4 | |
| SCHEMBL5760396 | 0.73 | CHIA (0.41) | ELANEKMT2A | |
| SCHEMBL5762922 | 0.73 | MCHR1 (0.47) | CYP1A2CYP2C19 | |
| SCHEMBL5759920 | 0.73 | TRPV1 (0.42) | — | |
| SCHEMBL5761733 | 0.73 | ELANE (0.37) | ELANE | |
| SCHEMBL5761129 | 0.72 | MCHR1 (0.45) | — | |
| SCHEMBL5763103 | 0.72 | HPGD (0.43) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101885-B2 | 1-(4-Bromo-phenyl)-3-[2-(4-methyl-piperazin-1-yl)-pyridin-3-yloxy]-pyrrolidin-2-one; antagonists of the serotonin 5HT1B receptor; treating depression | PFIZER INC (US) | 2006-09-05 | — | — | US | claimed |
| US-7101885-B2 | 1-(4-Bromo-phenyl)-3-[2-(4-methyl-piperazin-1-yl)-pyridin-3-yloxy]-pyrrolidin-2-one; antagonists of the serotonin 5HT1B receptor; treating depression | PFIZER INC (US) | 2006-09-05 | — | — | US | disclosed |