Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5761733 | 0.86 | ELANE (0.37) | ELANE | |
| SCHEMBL5847019 | 0.85 | ELANE (0.41) | ELANE | |
| SCHEMBL5807850 | 0.80 | PIK3CD (0.33) | ELANE | |
| SCHEMBL5846130 | 0.76 | POLB (0.39) | ELANE | |
| SCHEMBL5762196 | 0.74 | CHRNA7 (0.39) | ELANEHRH4 | |
| SCHEMBL5760136 | 0.74 | ROCK2 (0.51) | HRH4 | |
| SCHEMBL5846685 | 0.74 | ALDH1A1 (0.42) | HRH4 | |
| SCHEMBL5760396 | 0.72 | CHIA (0.41) | ELANEHRH4 | |
| SCHEMBL5762922 | 0.72 | MCHR1 (0.47) | — | |
| SCHEMBL5759920 | 0.72 | TRPV1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101885-B2 | 1-(4-Bromo-phenyl)-3-[2-(4-methyl-piperazin-1-yl)-pyridin-3-yloxy]-pyrrolidin-2-one; antagonists of the serotonin 5HT1B receptor; treating depression | PFIZER INC (US) | 2006-09-05 | — | — | US | claimed |
| US-7101885-B2 | 1-(4-Bromo-phenyl)-3-[2-(4-methyl-piperazin-1-yl)-pyridin-3-yloxy]-pyrrolidin-2-one; antagonists of the serotonin 5HT1B receptor; treating depression | PFIZER INC (US) | 2006-09-05 | — | — | US | disclosed |