⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16287785 | 0.73 | — | — | |
| SCHEMBL19834313 | 0.72 | — | — | |
| SCHEMBL196197 | 0.71 | — | — | |
| SCHEMBL3045930 | 0.71 | — | — | |
| SCHEMBL16288370 | 0.71 | TSHR (0.46) | — | |
| SCHEMBL19834301 | 0.70 | — | — | |
| SCHEMBL83588 | 0.68 | TSHR (0.42) | — | |
| Methylamine SCHEMBL27770755 | 0.67 | TSHR (0.39) | — | |
| SCHEMBL8874115 | 0.67 | — | — | |
| SCHEMBL2528376 | 0.67 | TSHR (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239786-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF CANCER | YALE UNIVERSITY | 2024-07-18 | — | — | US | claimed |
| WO-2022221181-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF CANCER | YALE UNIVERSITY (US) | 2022-10-20 | — | — | WO | claimed |
| EP-0937464-B1 | Combined pharmaceutical preparation containing inhibitors of the sodium hydrogen exchange and a medicament for the treatment of cardiovascular diseases | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-07-11 | — | — | EP | claimed |
| US-7144893-B2 | 4-aryl quinols and analogs thereof as therapeutic agents | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-12-05 | — | — | US | claimed |
| US-20040220236-A1 | 4-Aryl quinols and analogs thereof as therapeutic agents | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2004-11-04 | — | — | US | claimed |
| EP-1404659-A1 | 4-ARYL QUINOLS AND ANALOGS THEREOF AS THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2004-04-07 | — | — | EP | claimed |
| EP-0733900-B1 | Capillary electrophoresis detection and/or analysis method and unit | ANALIS SA (BE) | 2003-05-21 | — | — | EP | claimed |
| WO-2003004479-A1 | 4-ARYL QUINOLS AND ANALOGS THEREOF AS THERAPEUTIC AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2003-01-16 | — | — | WO | claimed |
| EP-1140056-A2 | THE UTILISATION OF INHIBITORS OF THE SODIUM HYDROGEN EXCHANGER FOR PRODUCING A MEDICAMENT FOR PREVENTING ORGAN DYSFUNCTIONS AND DISEASES RELATED TO A PARTICULAR AGE AND FOR PROLONGING LIFE | Aventis Pharma Deutschland GmbH (DE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000038661-A2 | THE UTILISATION OF INHIBITORS OF THE SODIUM HYDROGEN EXCHANGER FOR PRODUCING A MEDICAMENT FOR PREVENTING ORGAN DYSFUNCTIONS AND DISEASES RELATED TO A PARTICULAR AGE AND FOR PROLONGING LIFE | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-07-06 | — | — | WO | claimed |
| EP-0918515-A2 | USE OF INHIBITORS OF THE CELLULAR Na?+ /H?+ EXCHANGER (NHE) FOR PREPARING A MEDICAMENT FOR NORMALIZING SERUM LIPIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-06-02 | — | — | EP | claimed |
| EP-0916337-A2 | Use of inhibitors of the sodium-hydrogen exchange in the manufacture of amedicament for reducing unwanted effects of compounds on the heart. | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-19 | — | — | EP | claimed |
| EP-0909559-A2 | Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament for treatment or prophylaxis of diseases of the central nervous system | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-21 | — | — | EP | claimed |
| EP-0901788-A2 | Use of inhibitors of the sodium hydrogen exchange in the manufacture of a medicament | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-03-17 | — | — | EP | claimed |
| EP-0869779-A1 | USE OF INHIBITORS OF THE CELLULAR Na?+ /H?+ EXCHANGER (NHE) FOR THE PREPARATION OF A DRUG FOR RESPIRATORY STIMULATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-10-14 | — | — | EP | claimed |
| US-5733934-A | Antiarrythmic and cardioprotective substituted indenoylguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-31 | — | — | US | claimed |
| WO-1997046226-A2 | USE OF INHIBITORS OF THE CELLULAR Na+/H+ EXCHANGER (NHE) FOR PREPARING A MEDICAMENT FOR NORMALIZING SERUM LIPIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-11 | — | — | WO | claimed |
| WO-1997024113-A1 | USE OF INHIBITORS OF THE CELLULAR Na+/H+ EXCHANGER (NHE) FOR THE PREPARATION OF A DRUG FOR RESPIRATORY STIMULATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-07-10 | — | — | WO | claimed |
| EP-0738712-A1 | Anti-arrhythmic and cardioprotective substituted indenoylguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-10-23 | — | — | EP | claimed |
| EP-0733900-A2 | Capillary electrophoresis detection and/or analysis method and unit | ANALIS S.A. (BE) | 1996-09-25 | — | — | EP | claimed |