Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | HTR2C | P28335 | 1/20 | 0.66 |
| ▸ | HTR2B | P41595 | 1/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5416044 | 1.00 | HTR2A (0.66) | HTR2AHTR2CHTR2BEPHX2GPR119 | |
| SCHEMBL5848068 | 0.98 | HTR2A (0.65) | HTR2AHTR2CHTR2BEPHX2GPR119 | |
| SCHEMBL5847212 | 0.98 | HTR2A (0.63) | HTR2AHTR2CHTR2BEPHX2GPR119 | |
| SCHEMBL5847795 | 0.95 | HTR2A (0.59) | HTR2AHTR2CHTR2BEPHX2GPR119 | |
| SCHEMBL5848817 | 0.92 | HTR2A (0.56) | HTR2AHTR2CHTR2BEPHX2GPR119 | |
| SCHEMBL5849629 | 0.91 | HTR2A (0.53) | HTR2AHTR2CHTR2BGPR119 | |
| SCHEMBL5847589 | 0.91 | HTR2A (0.53) | HTR2AHTR2CHTR2BEPHX2GPR119 | |
| SCHEMBL5421176 | 0.90 | HTR2A (0.70) | HTR2AHTR2CHTR2BEPHX2PROKR1 | |
| SCHEMBL5847802 | 0.90 | HTR2A (0.53) | HTR2AHTR2CHTR2BEPHX2GPR119 | |
| SCHEMBL5847313 | 0.90 | HTR2A (0.51) | HTR2AHTR2CHTR2BEPHX2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |