Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 4/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5848913 | 1.00 | HTR2A (0.41) | HTR2AHTR2CHTR2BGPR119ALK | |
| SCHEMBL5847204 | 0.98 | GPR119 (0.40) | HTR2AHTR2CHTR2BGPR119ALK | |
| SCHEMBL5407323 | 0.88 | HTR2A (0.41) | HTR2AHTR2CHTR2BHRH2HRH1 | |
| SCHEMBL6918350 | 0.88 | HTR2A (0.41) | HTR2AHTR2CHTR2BHRH2HRH1 | |
| SCHEMBL5847313 | 0.87 | HTR2A (0.51) | HTR2AHTR2CHTR2BGPR119NPC1 | |
| SCHEMBL5410813 | 0.86 | HTR2A (0.39) | HTR2AHTR2CHTR2BHRH2HRH1 | |
| SCHEMBL5848103 | 0.85 | HTR2A (0.49) | HTR2AHTR2CHTR2BGPR119NPC1 | |
| SCHEMBL5847114 | 0.82 | HTR2A (0.45) | HTR2AHTR2CHTR2BGPR119 | |
| SCHEMBL5848567 | 0.82 | HTR2C (0.41) | HTR2AHTR2CHTR2BGPR119NPC1 | |
| SCHEMBL5849712 | 0.81 | USP30 (0.39) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |