Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14993702 | 0.75 | BACE1 (0.31) | BACE1 | |
| SCHEMBL146063 | 0.74 | GLA (0.37) | BACE1GLANPSR1TSHRPTPN1 | |
| SCHEMBL14993814 | 0.74 | — | — | |
| SCHEMBL27575442 | 0.72 | BACE1 (0.38) | BACE1GLANPSR1TSHRPTPN1 | |
| SCHEMBL588865 | 0.72 | GLA (0.36) | BACE1GLANPSR1TSHRPTPN1 | |
| SCHEMBL8409372 | 0.72 | GLA (0.36) | BACE1GLANPSR1TSHRPTPN1 | |
| SCHEMBL14306611 | 0.72 | GLA (0.36) | BACE1GLANPSR1TSHRPTPN1 | |
| SCHEMBL8163132 | 0.70 | GLA (0.47) | BACE1GLANPSR1TSHRPTPN1 | |
| SCHEMBL13502650 | 0.69 | GLA (0.34) | BACE1GLANPSR1TSHRPTPN1 | |
| SCHEMBL6059323 | 0.69 | GLA (0.50) | BACE1GLANPSR1TSHRPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9825331-B2 | Fluorinated derivatives of meldrum's acid, a method for the preparation of the same, and their use as a solvent additive | SOLVAY SA (BE) | 2017-11-21 | — | — | US | disclosed |
| US-9825331-B2 | Fluorinated derivatives of meldrum's acid, a method for the preparation of the same, and their use as a solvent additive | SOLVAY SA (BE) | 2017-11-21 | — | — | US | disclosed |
| US-9825331-B2 | Fluorinated derivatives of meldrum's acid, a method for the preparation of the same, and their use as a solvent additive | SOLVAY SA (BE) | 2017-11-21 | — | — | US | disclosed |
| EP-2785703-B1 | 5-Fluorinated derivatives of Meldrum's acid (5-fluoro-1,3-dioxane-4,6-dione derivatives), methods for their preparation and their use as solvent additives in lithium ion batteries. | SOLVAY (BE) | 2017-01-11 | — | — | EP | disclosed |
| WO-2016075085-A1 | FLUOROMALONYL HALFTHIOESTERS | ETH ZURICH (CH) | 2016-05-19 | — | — | WO | disclosed |
| WO-2016075085-A1 | FLUOROMALONYL HALFTHIOESTERS | ETH ZURICH (CH) | 2016-05-19 | — | — | WO | disclosed |
| EP-3020703-A1 | Fluoromalonyl Halfthioesters | ETH Zurich (CH) | 2016-05-18 | — | — | EP | disclosed |
| EP-3020703-A1 | Fluoromalonyl Halfthioesters | ETH Zurich (CH) | 2016-05-18 | — | — | EP | disclosed |
| US-20140322618-A1 | FLUORINATED DERIVATIVES OF MELDRUM'S ACID, A METHOD FOR THE PREPARATION OF THE SAME, AND THEIR USE AS A SOLVENT ADDITIVE | SOLVAY SA (BE) | 2014-10-30 | — | — | US | disclosed |
| US-20140322618-A1 | FLUORINATED DERIVATIVES OF MELDRUM'S ACID, A METHOD FOR THE PREPARATION OF THE SAME, AND THEIR USE AS A SOLVENT ADDITIVE | SOLVAY SA (BE) | 2014-10-30 | — | — | US | disclosed |
| US-20140322618-A1 | FLUORINATED DERIVATIVES OF MELDRUM'S ACID, A METHOD FOR THE PREPARATION OF THE SAME, AND THEIR USE AS A SOLVENT ADDITIVE | SOLVAY SA (BE) | 2014-10-30 | — | — | US | disclosed |
| EP-2785703-A1 | FLUORINATED DERIVATIVES OF MELDRUM'S ACID, A METHOD FOR THE PREPARATION OF THE SAME, AND THEIR USE AS A SOLVENT ADDITIVE | Solvay SA (BE) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013079397-A1 | FLUORINATED DERIVATIVES OF MELDRUM'S ACID, A METHOD FOR THE PREPARATION OF THE SAME, AND THEIR USE AS A SOLVENT ADDITIVE | SOLVAY SA (BE) | 2013-06-06 | — | — | WO | disclosed |
| EP-2417119-A2 | NO-CARRIER-ADDED NUCLEOPHILIC ÝF-18¨FLUORINATION OF AROMATIC COMPOUNDS | The Regents of The University of California (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117435-A2 | NO-CARRIER-ADDED NUCLEOPHILIC [F-18] FLUORINATION OF AROMATIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140322618-A1 | FLUORINATED DERIVATIVES OF MELDRUM'S ACID, A METHOD FOR THE PREPARATION OF THE SAME, AND THEIR USE AS A SOLVENT ADDITIVE | FXR2, FXR1, SLC10A1 | BACE1 4306/4885GLA 4020/4885NPSR1 1897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.