Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 9/20 | 0.40 |
| ▸ | CTSD | P07339 | 8/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5680280 | 0.76 | EPHB4 (0.45) | CYP11B2DHODHBACE1CTSDBACE2 | |
| SCHEMBL944215 | 0.75 | MKNK1 (0.44) | CYP11B2DHODHBACE1CTSDBACE2 | |
| SCHEMBL26785258 | 0.73 | MAP4K4 (0.69) | CYP11B2BACE1CTSDBACE2MAP4K4 | |
| SCHEMBL5654405 | 0.73 | MKNK1 (0.56) | CYP11B2MKNK1MKNK2 | |
| SCHEMBL5675922 | 0.72 | MAP4K4 (0.44) | CYP11B2DHODHBACE1CTSDMAP4K4 | |
| SCHEMBL3875933 | 0.70 | CYP11B2 (0.55) | CYP11B2DHODHBACE1MAP4K4MAPT | |
| SCHEMBL16675779 | 0.70 | PRKCI (0.51) | CYP11B2DHODHMAPTGSK3B | |
| SCHEMBL5654037 | 0.70 | PIM2 (0.67) | CYP11B2BACE1BACE2 | |
| SCHEMBL2825728 | 0.69 | NFE2L2 (0.56) | — | |
| SCHEMBL3876408 | 0.69 | DHODH (0.50) | CYP11B2DHODHNAPRTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144881-B2 | Arylcyclopropylcarboxylic amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-05 | — | — | US | disclosed |
| US-7135472-B2 | 3-Heterocyclic benzylamide derivatives as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-11-14 | — | — | US | disclosed |