Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 7/20 | 0.40 |
| ▸ | CTSD | P07339 | 6/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16675779 | 0.81 | PRKCI (0.51) | GSK3BDHODHCYP11B2 | |
| SCHEMBL5849946 | 0.76 | CYP11B2 (0.41) | GSK3BDHODHCYP11B2BACE1CTSD | |
| SCHEMBL28943563 | 0.75 | PLA2G10 (0.47) | EPHB4PLA2G10PLA2G2APOLQNPC1 | |
| SCHEMBL15782613 | 0.74 | ICMT (0.55) | — | |
| SCHEMBL5176875 | 0.74 | EPHX2 (0.55) | BACE1 | |
| SCHEMBL944215 | 0.74 | MKNK1 (0.44) | GSK3BDHODHCYP11B2BACE1CTSD | |
| SCHEMBL31310183 | 0.74 | HTR7 (0.60) | PLA2G10PLA2G2ARORC | |
| SCHEMBL5677385 | 0.73 | EPHB4 (0.46) | EPHB4DHODHNPC1HPGDNFKB1 | |
| SCHEMBL26785258 | 0.72 | MAP4K4 (0.69) | CYP11B2BACE1CTSDBACE2NPC1 | |
| SCHEMBL254913 | 0.72 | RORC (0.54) | PLA2G10PLA2G2ANPC1HPGDNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565190-A4 | ARYLCYCLOPROPYLCARBOXYLIC AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL MYERS SQUIBB CO (US) | 2006-04-26 | — | — | EP | disclosed |
| EP-1565190-A2 | ARYLCYCLOPROPYLCARBOXYLIC AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004047738-A2 | ARYLCYCLOPROPYLCARBOXYLIC AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |