SCHEMBL5850609

SCHEMBL5850609

Cc1ccc(S(=O)(=O)N(C)C2(C(=O)N[C@@H](Cc3ccc(NC(=O)c4ccncc4)cc3)C(=O)O)CCCC2)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 2/20 0.49
ITGA4 P13612 12/20 0.49
ITGB1 P05556 11/20 0.49
MEN1 O00255 2/20 0.44
ALDH1A1 P00352 2/20 0.44
KMT2A Q03164 2/20 0.44
MAPK1 P28482 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
ITGB3 P05106 1/20 0.44
ITGAV P06756 1/20 0.44
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43
ITGB7 P26010 1/20 0.42
MAPT P10636 1/20 0.42
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5850678 0.93 USP30 (0.44) MMP9ITGA4ITGB1MEN1ALDH1A1
SCHEMBL5850926 0.91 ALDH1A1 (0.45) MMP9ITGA4ITGB1MEN1ALDH1A1
SCHEMBL5850857 0.84 ITGB1 (0.64) ITGA4ITGB1ALDH1A1ITGB7TDP1
SCHEMBL5852274 0.84 ITGB1 (0.51) MMP9ITGA4ITGB1ITGB7
SCHEMBL7401948 0.82 ITGB1 (0.61) MMP9ITGA4ITGB1ALDH1A1ITGB7
SCHEMBL5850976 0.81 ITGB1 (0.47) MMP9ITGA4ITGB1ALDH1A1SMN1; SMN2
SCHEMBL5850545 0.79 ITGB1 (0.52) ITGA4ITGB1ITGB7TDP1
SCHEMBL5851039 0.77 ATM (0.55) ITGA4ITGB1ALDH1A1ITGB7
SCHEMBL5851025 0.77 CA1 (0.45) MMP9ITGA4ITGB1ALDH1A1KMT2A
SCHEMBL7409938 0.75 ATM (0.55) ITGA4ITGB1ALDH1A1KMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0994895-A1 DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-04-26 EP claimed
WO-1999006435-A1 DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO claimed
US-7030114-B1 Compounds which inhibit leukocyte adhesion mediated by VLA-4 ELAN PHARMACEUTICALS, INC. (US) 2006-04-18 US disclosed
EP-0994895-A1 DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-04-26 EP disclosed
WO-1999006435-A1 DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO disclosed