⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867530 | 0.71 | CHRNB2 (0.33) | — | |
| SCHEMBL587912 | 0.71 | ESR2 (0.31) | — | |
| SCHEMBL19498203 | 0.69 | PDE10A (0.34) | — | |
| SCHEMBL586982 | 0.69 | CHRNB2 (0.38) | — | |
| Hydrochloric Acid SCHEMBL587096 | 0.69 | ASIC3 (0.40) | — | |
| SCHEMBL13093365 | 0.67 | DPP4 (0.42) | — | |
| SCHEMBL7771023 | 0.62 | SIGMAR1 (0.46) | — | |
| SCHEMBL19700137 | 0.62 | KCNH2 (0.50) | — | |
| SCHEMBL17813373 | 0.60 | AKR1C3 (0.39) | — | |
| SCHEMBL5962445 | 0.60 | MAOB (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831199-B1 | MMP inhibitors | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| US-20100256166-A1 | Novel Hydantoin Derivatives as Metalloproteinase Inhibitors | ASTRAZENECA AB (SE) | 2010-10-07 | — | — | US | disclosed |
| US-7655664-B2 | Hydantoin derivatives as metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2010-02-02 | — | — | US | disclosed |
| US-20080293743-A1 | Novel Hydantoin Derivatives as Metalloproteinase Inhibitors | ASTRAZENECA AB (SE) | 2008-11-27 | — | — | US | disclosed |