Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.37 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.37 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5853189 | 1.00 | EPHX2 (0.40) | EPHX2MEN1KMT2AALDH1A1P2RX7 | |
| Hydrochloric Acid SCHEMBL5852857 | 0.99 | EPHX2 (0.38) | EPHX2MEN1KMT2AALDH1A1P2RX7 | |
| Hydrochloric Acid SCHEMBL5856408 | 0.96 | ADORA1 (0.36) | EPHX2MEN1KMT2AALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL5852977 | 0.87 | GAA (0.31) | ALDH1A1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5853962 | 0.83 | HSP90AA1 (0.36) | EPHX2MEN1KMT2AP2RX7LMNA | |
| Hydrochloric Acid SCHEMBL5855880 | 0.83 | HSP90AA1 (0.36) | EPHX2MEN1KMT2AP2RX7LMNA | |
| Hydrochloric Acid SCHEMBL5853547 | 0.82 | HSP90AA1 (0.34) | MEN1KMT2AALDH1A1P2RX7LMNA | |
| Hydrochloric Acid SCHEMBL6697575 | 0.81 | KCNH3 (0.33) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5853444 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL5853092 | 0.81 | MAPK1 (0.42) | MEN1KMT2AALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037989-B2 | Copolymers of ethylene and/or α-olefins and vicinally disubstituted olefins | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2006-05-02 | — | — | US | disclosed |
| US-20040242814-A1 | COPOLYMERS OF ETHYLENE AND/OR ALPHA-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-12-02 | — | — | US | disclosed |