Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 2/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F11 | P03951 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17783165 | 0.84 | HIF1A (0.37) | LIPEUCHL1EGFRCSF1RHIF1A | |
| SCHEMBL276100 | 0.82 | CXCR2 (0.34) | LIPECXCR2F2F11PRSS1 | |
| SCHEMBL3766206 | 0.80 | LIPE (0.32) | LIPECXCR2F2F11PRSS1 | |
| SCHEMBL31651749 | 0.79 | USP30 (0.38) | LIPEUCHL1NR1I2DGAT1EGFR | |
| SCHEMBL28892512 | 0.79 | EGFR (0.35) | UCHL1EGFR | |
| SCHEMBL28913007 | 0.79 | LIPE (0.31) | LIPECXCR2 | |
| SCHEMBL18896594 | 0.79 | USP30 (0.38) | LIPEUCHL1NR1I2DGAT1EGFR | |
| SCHEMBL31651926 | 0.77 | NQO2 (0.36) | EGFRCSF1R | |
| SCHEMBL9938876 | 0.77 | UCHL1 (0.33) | UCHL1CSF1R | |
| SCHEMBL17102719 | 0.76 | ALDH1A1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143393-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-27 | — | — | US | disclosed |