Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.50 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.50 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 9/20 | 0.49 |
| ▸ | ITGAV | P06756 | 9/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CTSA | P10619 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22775935 | 0.90 | TBXAS1 (0.48) | TBXAS1SMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL25151973 | 0.87 | ITGB3 (0.46) | TBXAS1SMN1; SMN2ITGB3ITGAVITGB1 | |
| SCHEMBL25152268 | 0.87 | ITGB3 (0.46) | TBXAS1SMN1; SMN2ITGB3ITGAVITGB1 | |
| SCHEMBL27396676 | 0.85 | ITGB3 (0.45) | TBXAS1ITGB3ITGAVITGB1ITGB6 | |
| SCHEMBL25152853 | 0.85 | ITGB3 (0.52) | TBXAS1SMN1; SMN2GABBR2GABBR1NAPRT | |
| SCHEMBL25152816 | 0.85 | ITGB3 (0.52) | TBXAS1SMN1; SMN2GABBR2GABBR1NAPRT | |
| SCHEMBL25152800 | 0.85 | ITGB3 (0.52) | TBXAS1SMN1; SMN2GABBR2GABBR1NAPRT | |
| SCHEMBL3067372 | 0.84 | SMN1; SMN2 (0.55) | TBXAS1SMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL11990053 | 0.84 | TBXAS1 (0.63) | TBXAS1SMN1; SMN2CFTRSLC6A2SLC6A4 | |
| SCHEMBL4459275 | 0.84 | SMN1; SMN2 (0.55) | TBXAS1SMN1; SMN2CFTRSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119098-B2 | Heteroarylakanoic acids as intergrin receptor antagonists | PHARMACIA CORPORATION (US) | 2006-10-10 | — | — | US | disclosed |
| US-6933304-B2 | Heteroarylalkanoic acids as integrin receptor antagonists | PHARMACIA CORPORATION (US) | 2005-08-23 | — | — | US | disclosed |
| US-20040092497-A1 | Heteroarylakanoic acids as intergrin receptor antagonists | PHARMACIA CORPORATION | 2004-05-13 | — | — | US | disclosed |
| EP-1289983-A2 | HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS | Pharmacia Corporation (US) | 2003-03-12 | — | — | EP | disclosed |
| US-20020133023-A1 | Heteroarylalkanoic acids as integrin receptor antagonists | PHARMACIA CORPORATION | 2002-09-19 | — | — | US | disclosed |
| WO-2001096334-A2 | HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS | PHARMACIA CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-1993003045-A1 | PROCESS FOR PURER ORGANIC METAL ION CHELATE COMPLEXES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020133023-A1 | Heteroarylalkanoic acids as integrin receptor antagonists | ITGA5, ITGA2B, ITGAV | TBXAS1 811/4885SMN1; SMN2 3712/4885CFTR 224/4885 |
| US-20040092497-A1 | Heteroarylakanoic acids as intergrin receptor antagonists | ITGA5, ITGB7, ITGA2B | TBXAS1 379/4885SMN1; SMN2 4329/4885CFTR 905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.