Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099655 | 0.86 | FFAR3 (0.38) | LDHASRR | |
| SCHEMBL9099659 | 0.86 | FFAR3 (0.38) | LDHASRR | |
| SCHEMBL9097305 | 0.83 | HDAC3 (0.41) | LDHASRRTSHRALOX15HSD17B10 | |
| SCHEMBL9097309 | 0.83 | HDAC3 (0.41) | LDHASRRTSHRALOX15HSD17B10 | |
| SCHEMBL19066916 | 0.75 | — | — | |
| SCHEMBL19066917 | 0.75 | — | — | |
| SCHEMBL1762775 | 0.73 | GAA (0.42) | KDM4ETSHRHSD17B10 | |
| Malonic Acid SCHEMBL21815791 | 0.65 | — | — | |
| Malonic Acid SCHEMBL2321038 | 0.65 | — | — | |
| Malonic Acid SCHEMBL4306981 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982333-B2 | Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2006-01-03 | — | — | US | disclosed |
| US-20040063947-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH | 2004-04-01 | — | — | US | disclosed |
| US-6620937-B2 | Annulation, cyclization | UNIVERSITY OF PITTSBURGH | 2003-09-16 | — | — | US | disclosed |
| US-6376676-B1 | CAPROLACTAM COMPOUND | UNIVERSITY OF PITTSBURGH | 2002-04-23 | — | — | US | disclosed |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-10-11 | — | — | US | disclosed |
| US-6252079-B1 | CYCLIZATION OF CHEMICAL INTERMEDIATE; REACTING WITH ARYL ISONITRILE | UNIVERSITY OF PITTSBURGH | 2001-06-26 | — | — | US | disclosed |
| US-6239278-B1 | Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH | 2001-05-29 | — | — | US | disclosed |
| US-6211371-B1 | REACTING AN ARYL ISONIRILE WITH AN ISOQUINOLIN-1-ONE COMPOUND | UNIVERSITY OF PITTSBURGH | 2001-04-03 | — | — | US | disclosed |
| US-6034243-A | Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2000-03-07 | — | — | US | disclosed |
| WO-1999001456-A1 | SYNTHESIS OF AND INTERMEDIATES FOR CAMPTOTHECINS | UNIVERSITY OF PITTSBURGH (US) | 1999-01-14 | — | — | WO | disclosed |
| US-5744605-A | ANNULATION; CYCLIZATION | UNIVERSITY OF PITTSBURGH (US) | 1998-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063947-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | CGAS, APEX1, DHPS | LDHA 1405/4885SRR 2660/4885KDM4E 3912/4885 |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | CGAS, APEX1, DHPS | LDHA 1405/4885SRR 2660/4885KDM4E 3912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.