Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | POLA1 | P09884 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12593429 | 0.90 | MGAM (0.38) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL4608566 | 0.80 | MGAM (0.46) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL4608567 | 0.80 | MGAM (0.46) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL1763000 | 0.75 | GAA (0.47) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL9408203 | 0.74 | GAA (0.50) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL9408202 | 0.74 | GAA (0.50) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL5857009 | 0.73 | LDHA (0.40) | TSHRHSD17B10KDM4E | |
| SCHEMBL14306479 | 0.72 | MGAM (0.52) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL13155816 | 0.71 | GAA (0.47) | GAAMGAMSIMGAM2TSHR | |
| SCHEMBL3108045 | 0.71 | GAA (0.47) | GAAMGAMSIMGAM2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951811-B2 | Antagonist against corticotropen releasing factor receptors; antidepressants, anxiolytic agents, Alzheimer's disease; Parkinson's disease; eating disorders; hypotensive agents; gastrointestinal disorders; drug abuse; brain disorders; antiischemic agents; antiinflammatory agents; immunotherapy; alopecia | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-7951811-B2 | Antagonist against corticotropen releasing factor receptors; antidepressants, anxiolytic agents, Alzheimer's disease; Parkinson's disease; eating disorders; hypotensive agents; gastrointestinal disorders; drug abuse; brain disorders; antiischemic agents; antiinflammatory agents; immunotherapy; alopecia | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-7951811-B2 | Antagonist against corticotropen releasing factor receptors; antidepressants, anxiolytic agents, Alzheimer's disease; Parkinson's disease; eating disorders; hypotensive agents; gastrointestinal disorders; drug abuse; brain disorders; antiischemic agents; antiinflammatory agents; immunotherapy; alopecia | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-05-31 | — | — | US | disclosed |
| US-20110124862-A1 | PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-05-26 | — | — | US | disclosed |
| US-20080280928-A1 | Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with a Cyclic Amino Group As Crf Antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-11-13 | — | — | US | disclosed |
| US-20080280928-A1 | Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with a Cyclic Amino Group As Crf Antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-11-13 | — | — | US | disclosed |
| US-20080280928-A1 | Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with a Cyclic Amino Group As Crf Antagonists | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-11-13 | — | — | US | disclosed |
| EP-1953160-A1 | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with a cyclic amino group as CRF antagonists | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953160-A1 | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with a cyclic amino group as CRF antagonists | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1758903-A1 | PYRROLOPYRAMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2007-03-07 | — | — | EP | disclosed |
| US-20040063947-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH | 2004-04-01 | — | — | US | disclosed |
| US-6620937-B2 | Annulation, cyclization | UNIVERSITY OF PITTSBURGH | 2003-09-16 | — | — | US | disclosed |
| US-6376676-B1 | CAPROLACTAM COMPOUND | UNIVERSITY OF PITTSBURGH | 2002-04-23 | — | — | US | disclosed |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-10-11 | — | — | US | disclosed |
| US-6252079-B1 | CYCLIZATION OF CHEMICAL INTERMEDIATE; REACTING WITH ARYL ISONITRILE | UNIVERSITY OF PITTSBURGH | 2001-06-26 | — | — | US | disclosed |
| US-6239278-B1 | Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH | 2001-05-29 | — | — | US | disclosed |
| US-6211371-B1 | REACTING AN ARYL ISONIRILE WITH AN ISOQUINOLIN-1-ONE COMPOUND | UNIVERSITY OF PITTSBURGH | 2001-04-03 | — | — | US | disclosed |
| US-6034243-A | Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2000-03-07 | — | — | US | disclosed |
| WO-1999001456-A1 | SYNTHESIS OF AND INTERMEDIATES FOR CAMPTOTHECINS | UNIVERSITY OF PITTSBURGH (US) | 1999-01-14 | — | — | WO | disclosed |
| US-5744605-A | ANNULATION; CYCLIZATION | UNIVERSITY OF PITTSBURGH (US) | 1998-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280928-A1 | Pyrrolopyrimidine and Pyrrolopyridine Derivatives Substituted with a Cyclic Amino Group As Crf Antagonists | CRHR1, CRHR2, HRH4 | GAA 2442/4885MGAM 4355/4885SI 731/4885 |
| US-20040063947-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | CGAS, APEX1, DHPS | GAA 3286/4885MGAM 3185/4885SI 2280/4885 |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | CGAS, APEX1, DHPS | GAA 3286/4885MGAM 3185/4885SI 2280/4885 |
| US-20110124862-A1 | PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES SUBSTITUTED WITH A CYCLIC AMINO GROUP AS CRF ANTAGONISTS | CRHR1, HRH2, CRHR2 | GAA 2461/4885MGAM 4407/4885SI 807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.