Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28103828 | 0.84 | ALDH1A1 (0.46) | LMNAKDM4ETDP1ALDH1A1CYP2C19 | |
| Hydrogen Sulfide SCHEMBL28104139 | 0.83 | ALDH1A1 (0.45) | LMNAKDM4ETDP1ALDH1A1CYP2C19 | |
| SCHEMBL2899641 | 0.81 | APEX1 (0.48) | KDM4EALDH1A1MEN1HPGDMAPK1 | |
| SCHEMBL5796882 | 0.75 | KDM4E (0.41) | LMNAKDM4ETDP1ALDH1A1MAPT | |
| SCHEMBL6280753 | 0.75 | ALDH1A1 (0.47) | LMNATDP1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL294649 | 0.74 | PARP1 (0.36) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL5272693 | 0.74 | ALDH1A1 (0.53) | LMNAKDM4EGSK3AGSK3BALDH1A1 | |
| SCHEMBL21463358 | 0.73 | LMNA (0.71) | LMNAKDM4EDAORAB9ANPC1 | |
| SCHEMBL14491 | 0.73 | TYMP (0.49) | DAORAB9ANPC1GSK3AGSK3B | |
| SCHEMBL667246 | 0.72 | KDM4E (0.54) | KDM4ENPC1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045509-B2 | Proteins and nucleic acids encoding same | CURAGEN CORPORATION (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040005576-A1 | Proteins and nucleic acids encoding same | CURAGEN CORPORATION | 2004-01-08 | — | — | US | disclosed |
| EP-1366162-A2 | PUTATIVE PROTEINS AND NUCLEIC ACIDS ENCODING SAME | Curagen Corporation (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002046409-A2 | PROTEINS AND NUCLEIC ACIDS ENCODING SAME | CURAGEN CORPORATION (US) | 2002-06-13 | — | — | WO | disclosed |