SCHEMBL5860670

SCHEMBL5860670

CC(=O)Nc1cc2ccccc2cc1C(=O)O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.70
ABCC1 P33527 1/20 0.63
MAPT P10636 3/20 0.62
GFER P55789 2/20 0.62
NGLY1 Q96IV0 1/20 0.62
KDM4E B2RXH2 6/20 0.56
HSD17B10 Q99714 5/20 0.56
ALDH1A1 P00352 5/20 0.55
HPGD P15428 4/20 0.55
AKR1C3 P42330 1/20 0.55
AKR1C2 P52895 1/20 0.55
AKR1C1 Q04828 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
CYP1A2 P05177 2/20 0.51
LMNA P02545 1/20 0.51
MAOA P21397 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
GRIK1 P39086 2/20 0.51
KMT2A Q03164 2/20 0.50
IDO1 P14902 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7527927 0.85 KDM4E (0.61) MAPTGFERKDM4EHSD17B10ALDH1A1
SCHEMBL14344899 0.83 MEN1 (0.56) PTPN1MAPTGFERNGLY1HSD17B10
SCHEMBL14503727 0.83 KDM4E (0.54) PTPN1ABCC1MAPTGFERNGLY1
SCHEMBL4311266 0.82 PTPN1 (1.00) PTPN1ABCC1MAPTGFERNGLY1
SCHEMBL10796972 0.81 MAPT (0.66) PTPN1ABCC1MAPTGFERNGLY1
SCHEMBL14398972 0.81 PTPN1 (0.59) PTPN1ABCC1MAPTGFERNGLY1
SCHEMBL2841346 0.79 PTPN1 (0.66) PTPN1ABCC1MAPTGFERNGLY1
SCHEMBL1308196 0.79 CYP1A2 (0.61) PTPN1ABCC1MAPTGFERNGLY1
SCHEMBL8893663 0.78 PTPN1 (0.64) PTPN1ABCC1MAPTGFERNGLY1
SCHEMBL5391933 0.78 MAPT (0.66) PTPN1ABCC1MAPTGFERNGLY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2644639-B1 METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN AND METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN COMPOUND SHENZHEN WOTE ADVANCED MAT CO LTD (CN) 2017-09-20 EP claimed
US-8859711-B2 Method for preparing wholly aromatic liquid crystalline polyester amide resin and method for preparing wholly aromatic liquid crystalline polyester amide resin compound SAMSUNG FINE CHEMICALS CO., LTD. (KR) 2014-10-14 US claimed
EP-2644639-A2 METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN AND METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN COMPOUND Samsung Fine Chemicals Co., Ltd. (KR) 2013-10-02 EP claimed
US-20130231453-A1 METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN AND METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN COMPOUND SAMSUNG FINE CHEMICALS CO., LTD. (KR) 2013-09-05 US claimed
JP-4225068-A None JP disclosed
EP-2644639-B1 METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN AND METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN COMPOUND SHENZHEN WOTE ADVANCED MAT CO LTD (CN) 2017-09-20 EP disclosed
US-9561201-B2 Therapeutic compounds FIBROTECH THERAPEUTICS PTY LTD (AU) 2017-02-07 US disclosed
US-20140357628-A1 THERAPEUTIC COMPOUNDS FIBROTECH THERAPEUTICS PTY LTD (AU) 2014-12-04 US disclosed
US-8859711-B2 Method for preparing wholly aromatic liquid crystalline polyester amide resin and method for preparing wholly aromatic liquid crystalline polyester amide resin compound SAMSUNG FINE CHEMICALS CO., LTD. (KR) 2014-10-14 US disclosed
EP-2644639-A2 METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN AND METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN COMPOUND Samsung Fine Chemicals Co., Ltd. (KR) 2013-10-02 EP disclosed
US-20130231453-A1 METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN AND METHOD FOR PREPARING WHOLLY AROMATIC LIQUID CRYSTALLINE POLYESTER AMIDE RESIN COMPOUND SAMSUNG FINE CHEMICALS CO., LTD. (KR) 2013-09-05 US disclosed
US-6989384-B2 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis AGOURON PHARMACEUTICALS, INC. (US) 2006-01-24 US disclosed
US-20050080121-A1 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis AGOURON PHARMACEUTICALS, INC. 2005-04-14 US disclosed
EP-1355878-A2 ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND MATERIALS FOR THEIR SYNTHESIS AGOURON PHARMACEUTICALS, INC. (US) 2003-10-29 EP disclosed
US-6632825-B2 Picornaviral 3C protease enzyme inhibitors; amide ester or amide acid derivatives AGOURON PHARMACEUTICALS, INC. 2003-10-14 US disclosed
US-20020061916-A1 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis AGOURON PHARMACEUTICALS, INC. 2002-05-23 US disclosed
WO-2001096297-A2 ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND MATERIALS FOR THEIR SYNTHESIS AGOURON PHARMACEUTICALS, INC. (US) 2001-12-20 WO disclosed
JP-H04225068-A AZO COMPOUND AND SENSITIZING SUBSTANCE USING THE SAME COMPOUND MITSUI TOATSU CHEM INC 1992-08-14 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140357628-A1 THERAPEUTIC COMPOUNDS NFATC1, AADAC, NAT1 PTPN1 4066/4885ABCC1 2557/4885MAPT 2890/4885
US-20050080121-A1 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis PRCP, RNPEP, SARNP PTPN1 2631/4885ABCC1 2773/4885MAPT 1853/4885
US-20020061916-A1 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis PRCP, RNASEL, RNASEH1 PTPN1 2799/4885ABCC1 2380/4885MAPT 1945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.