Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 17/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5860806 | 0.87 | CCR5 (0.87) | CCR5SIGMAR1 | |
| SCHEMBL13929210 | 0.84 | SIGMAR1 (0.69) | CCR5SIGMAR1ACKR3 | |
| SCHEMBL6699449 | 0.81 | CCR5 (0.69) | CCR5 | |
| SCHEMBL5862128 | 0.80 | CCR5 (1.00) | CCR5SIGMAR1 | |
| SCHEMBL5861278 | 0.80 | CCR5 (1.00) | CCR5SIGMAR1 | |
| SCHEMBL5862111 | 0.80 | CCR5 (1.00) | CCR5SIGMAR1 | |
| SCHEMBL7773120 | 0.80 | CCR5 (0.68) | CCR5 | |
| SCHEMBL7776703 | 0.80 | CCR5 (0.68) | CCR5 | |
| SCHEMBL14514119 | 0.79 | CCR5 (0.70) | CCR5 | |
| SCHEMBL5633715 | 0.78 | CCR5 (0.62) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1013276-A1 | Aminoazacycloalkanes as CCR5 modulators | PFIZER INC. (US) | 2000-06-28 | — | — | EP | claimed |
| US-7041667-B1 | CCR5 modulators | PFIZER, INC. (US) | 2006-05-09 | — | — | US | disclosed |
| US-20010039026-A1 | Assay method | PFIZER INC. | 2001-11-08 | — | — | US | disclosed |
| EP-1118858-A2 | Assay method | Pfizer Limited (GB) | 2001-07-25 | — | — | EP | disclosed |
| EP-1013276-A1 | Aminoazacycloalkanes as CCR5 modulators | PFIZER INC. (US) | 2000-06-28 | — | — | EP | disclosed |