Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656023 | 0.82 | ALDH1A1 (0.48) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14909620 | 0.82 | ALDH1A1 (0.43) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL31169320 | 0.79 | ADORA2A (0.44) | ALDH1A1ADORA2APOLBTDP1MAPT | |
| SCHEMBL4719658 | 0.78 | ALDH1A1 (0.59) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5860843 | 0.78 | MCHR1 (0.43) | ALDH1A1CHRM1POLBMEN1KMT2A | |
| SCHEMBL5860813 | 0.77 | MCHR1 (0.43) | ALDH1A1CHRM1POLBMEN1KMT2A | |
| SCHEMBL11540231 | 0.76 | ALDH1A1 (0.44) | ALDH1A1ADORA2APOLBMEN1KMT2A | |
| SCHEMBL17610365 | 0.75 | ALDH1A1 (0.40) | ALDH1A1POLBPABPC1MEN1LMNA | |
| SCHEMBL28083441 | 0.74 | POLB (0.41) | ALDH1A1POLBMEN1LMNAKMT2A | |
| SCHEMBL18131158 | 0.73 | ALDH1A1 (0.37) | ALDH1A1POLBPABPC1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049307-B2 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES (US) | 2006-05-23 | — | — | US | disclosed |
| US-20050187279-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBVIE INC. | 2005-08-25 | — | — | US | disclosed |
| US-20050137187-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABBOTT LABORATORIES | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137187-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | ALDH1A1 2303/4885CHRM2 731/4885CHRM1 701/4885 |
| US-20050187279-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | ALDH1A1 2303/4885CHRM2 731/4885CHRM1 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.