Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3450045 | 1.00 | CYP2D6 (0.48) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL683739 | 1.00 | CYP2D6 (0.48) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL3450044 | 1.00 | CYP2D6 (0.48) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL683685 | 0.86 | CHRM2 (0.36) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL7208477 | 0.83 | CHRM2 (0.34) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL7208474 | 0.83 | CHRM2 (0.34) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL16397618 | 0.82 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL16397424 | 0.82 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL12896178 | 0.82 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 | |
| SCHEMBL16397280 | 0.82 | CYP2D6 (0.43) | CYP2D6CYP1A2ALOX15CYP2C19SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030280-B2 | Process for producing optically active β-trifluoromethyl-β-hydroxycarbonyl compound | CENTRAL GLASS COMPANY, LIMITED (JP) | 2006-04-18 | — | — | US | claimed |
| US-20050119507-A1 | Process for producing optically active beta-trifluoromethyl-beta-hydroxycarbonyl compound | CENTRAL GLASS COMPANY, LIMITED (JP) | 2005-06-02 | — | — | US | claimed |
| US-5494898-A | DIQUATERNARY TRIPEPTIDES | OHMEDA PHARMACEUTICAL PRODUCTS DIVISION INC. (US) | 1996-02-27 | — | — | US | claimed |
| US-10611727-B2 | 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives | UNIVERSITAT DE BARCELONA (ES) | 2020-04-07 | — | — | US | disclosed |
| US-10611727-B2 | 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives | UNIVERSITAT DE BARCELONA (ES) | 2020-04-07 | — | — | US | disclosed |
| US-20190084927-A1 | 1-[1-(BENZOYL)-PYRROLIDINE-2-CARBONYL]-PYRROLIDINE-2-CARBONITRILE DERIVATIVES | UNIVERSITAT DE BARCELONA (ES) | 2019-03-21 | — | — | US | disclosed |
| US-20190084927-A1 | 1-[1-(BENZOYL)-PYRROLIDINE-2-CARBONYL]-PYRROLIDINE-2-CARBONITRILE DERIVATIVES | UNIVERSITAT DE BARCELONA (ES) | 2019-03-21 | — | — | US | disclosed |
| US-10125097-B2 | 1- [1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives | UNIVERSITAT DE BARCELONA (ES) | 2018-11-13 | — | — | US | disclosed |
| EP-2796546-B1 | Incorporation of unnatural amino acids | SCRIPPS RESEARCH INST (US) | 2017-08-09 | — | — | EP | disclosed |
| EP-2917209-B1 | 1-[1-(BENZOYL)-PYRROLIDINE-2-CARBONYL]-PYRROLIDINE-2-CARBONITRILE DERIVATIVES | UNIV BARCELONA (ES) | 2017-02-08 | — | — | EP | disclosed |
| EP-2917209-B1 | 1-[1-(BENZOYL)-PYRROLIDINE-2-CARBONYL]-PYRROLIDINE-2-CARBONITRILE DERIVATIVES | UNIV BARCELONA (ES) | 2017-02-08 | — | — | EP | disclosed |
| WO-2013186550-A1 | COMPOUND AND METHOD | UNIVERSITY OF BRISTOL (GB) | 2013-12-19 | — | — | WO | disclosed |
| US-20120202243-A1 | IN Vivo Incorporation of Unnatural Amino Acids | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-09 | — | — | US | disclosed |
| US-8012739-B2 | Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-09-06 | — | — | US | disclosed |
| US-20090068717-A1 | In vivo incorporation of unnatural amino acids | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| US-20080227152-A1 | Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-18 | — | — | US | disclosed |
| US-7030280-B2 | Process for producing optically active β-trifluoromethyl-β-hydroxycarbonyl compound | CENTRAL GLASS COMPANY, LIMITED (JP) | 2006-04-18 | — | — | US | disclosed |
| US-20050119507-A1 | Process for producing optically active beta-trifluoromethyl-beta-hydroxycarbonyl compound | CENTRAL GLASS COMPANY, LIMITED (JP) | 2005-06-02 | — | — | US | disclosed |
| US-5494898-A | DIQUATERNARY TRIPEPTIDES | OHMEDA PHARMACEUTICAL PRODUCTS DIVISION INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5494898-A | DIQUATERNARY TRIPEPTIDES | OHMEDA PHARMACEUTICAL PRODUCTS DIVISION INC. (US) | 1996-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190084927-A1 | 1-[1-(BENZOYL)-PYRROLIDINE-2-CARBONYL]-PYRROLIDINE-2-CARBONITRILE DERIVATIVES | BDNF, GRIN1, NLN | CYP2D6 644/4885CYP1A2 153/4885ALOX15 1082/4885 |
| US-10611727-B2 | 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives | BDNF, GRIN1, NLN | CYP2D6 644/4885CYP1A2 153/4885ALOX15 1082/4885 |
| US-10125097-B2 | 1- [1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives | BDNF, GRIN2A, NLN | CYP2D6 1173/4885CYP1A2 403/4885ALOX15 1345/4885 |
| US-20050119507-A1 | Process for producing optically active beta-trifluoromethyl-beta-hydroxycarbonyl compound | CYP8B1, HCCS, DHPS | CYP2D6 490/4885CYP1A2 251/4885ALOX15 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.