Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28658926 | 0.92 | HTT (0.47) | HTTEPHX2SMN1; SMN2CNR2HSD17B10 | |
| SCHEMBL25225127 | 0.83 | HTT (0.47) | HTTEPHX2CNR2MAPTALDH1A1 | |
| SCHEMBL28171366 | 0.81 | SIGMAR1 (0.44) | EPHX2SMN1; SMN2NPC1LMNAMAPT | |
| SCHEMBL5862098 | 0.78 | SIGMAR1 (0.67) | SMN1; SMN2NPC1MAPTALDH1A1MEN1 | |
| SCHEMBL28664079 | 0.76 | MAPT (0.53) | HTTSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL5861982 | 0.75 | EPHX2 (0.74) | HTTEPHX2SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL5963579 | 0.73 | EPHX2 (0.56) | HTTEPHX2SMN1; SMN2NPC1LMNA | |
| SCHEMBL3175750 | 0.73 | EPHX2 (0.56) | HTTEPHX2SMN1; SMN2NPC1LMNA | |
| SCHEMBL3172394 | 0.72 | EPHX2 (0.54) | HTTEPHX2SMN1; SMN2NPC1LMNA | |
| SCHEMBL5964054 | 0.72 | EPHX2 (0.54) | HTTEPHX2SMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041667-B1 | CCR5 modulators | PFIZER, INC. (US) | 2006-05-09 | — | — | US | disclosed |