Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25228282 | 0.87 | GPR119 (0.56) | SMN1; SMN2ANO1STSGPR119 | |
| SCHEMBL4213092 | 0.80 | ALDH1A1 (0.67) | MAPTSMN1; SMN2LMNAALDH1A1STS | |
| SCHEMBL5862098 | 0.77 | SIGMAR1 (0.67) | MAPTSMN1; SMN2ALDH1A1CACNA1HCYP2D6 | |
| SCHEMBL2445002 | 0.76 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2LMNAALDH1A1SIGMAR1 | |
| SCHEMBL27090313 | 0.76 | LMNA (0.53) | MAPTSMN1; SMN2LMNAALDH1A1STS | |
| SCHEMBL5862047 | 0.76 | HTT (0.55) | MAPTSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL10039879 | 0.76 | ALDH1A1 (0.62) | MAPTSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL24097945 | 0.76 | ALDH1A1 (0.50) | MAPTSMN1; SMN2LMNAALDH1A1STS | |
| SCHEMBL12493302 | 0.76 | MAPT (0.55) | MAPTSMN1; SMN2LMNAALDH1A1STS | |
| SCHEMBL28525675 | 0.76 | LMNA (0.55) | MAPTSMN1; SMN2LMNAALDH1A1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113683610-B | RET inhibitor, pharmaceutical composition and application thereof | 广东东阳光药业股份有限公司 | 2025-02-25 | — | — | CN | disclosed |
| CN-113683610-A | RET inhibitor, pharmaceutical composition and application thereof | 广东东阳光药业有限公司 | 2021-11-23 | — | — | CN | disclosed |