Sugi Predict

Sugi Predict / Compounds / SCHEMBL5862213

SCHEMBL5862213

SCHEMBL5862213

CCN1C(=O)C(F)(F)c2cc(N3C[C@H](C(N)=O)OC3=O)ccc21

nearest known ligand 0.46

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 8/20 0.46
▸ MAOB P27338 7/20 0.36
▸ LMNA P02545 2/20 0.36
▸ PTGS1 P23219 1/20 0.36
▸ CALML3 P27482 1/20 0.36
▸ SDHA P31040 1/20 0.36
▸ F10 P00742 1/20 0.34
▸ ALDH1A1 P00352 2/20 0.33
▸ HTT P42858 1/20 0.33
▸ GRM2 Q14416 1/20 0.33
▸ PKM P14618 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5861006 0.92 MAOA (0.37) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5861012 0.89 MAOB (0.36) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5862835 0.86 MAOA (0.48) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5862127 0.81 MAOA (0.58) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5504081 0.78 MAOA (0.48) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5862218 0.78 MAOA (0.39) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL3041390 0.76 MAOA (0.47) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL5860953 0.75 MAOA (0.37) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL3032928 0.74 MAOA (0.47) MAOAMAOBLMNAPTGS1CALML3
SCHEMBL14595582 0.73 MAOA (0.46) MAOAMAOBLMNAPTGS1CALML3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7012088-B2 Indolone oxazolidinones and derivatives thereof PHARMACIA & UPJOHN COMPANY (US) 2006-03-14 — — US claimed
EP-1599470-A1 ANTIBACTERIAL INDOLONE OXAZOLIDINONES, INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Pharmacia & Upjohn Company LLC (US) 2005-11-30 — — EP claimed
US-20040176610-A1 Indolone oxazolidinones and derivatives thereof PHARMACIA & UPJOHN COMPANY 2004-09-09 — — US claimed
WO-2004074282-A1 ANTIBACTERIAL INDOLONE OXAZOLIDINONES, INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PHARMACIA & UPJOHN COMPANY LLC (US) 2004-09-02 — — WO claimed
US-7012088-B2 Indolone oxazolidinones and derivatives thereof PHARMACIA & UPJOHN COMPANY (US) 2006-03-14 — — US disclosed
EP-1599470-A1 ANTIBACTERIAL INDOLONE OXAZOLIDINONES, INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Pharmacia & Upjohn Company LLC (US) 2005-11-30 — — EP disclosed
US-20040176610-A1 Indolone oxazolidinones and derivatives thereof PHARMACIA & UPJOHN COMPANY 2004-09-09 — — US disclosed
WO-2004074282-A1 ANTIBACTERIAL INDOLONE OXAZOLIDINONES, INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PHARMACIA & UPJOHN COMPANY LLC (US) 2004-09-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040176610-A1 Indolone oxazolidinones and derivatives thereof OXA1L, IDO1, NDUFS7 MAOA 635/4885MAOB 670/4885LMNA 2881/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.