Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 8/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.38 |
| ▸ | TTR | P02766 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.38 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.38 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.38 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585080 | 0.90 | CXCL8 (0.48) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL576761 | 0.79 | CXCL8 (0.54) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL576889 | 0.78 | CXCL8 (0.52) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL577294 | 0.74 | TTR (0.54) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL585610 | 0.72 | CXCL8 (0.47) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL13186033 | 0.72 | CXCL8 (0.68) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL576626 | 0.71 | CXCL8 (0.46) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL576745 | 0.70 | CXCL8 (0.43) | CXCL8PTGS2TTRPTGS1AKR1B10 | |
| SCHEMBL586141 | 0.70 | PTGS2 (0.49) | CXCL8PTGS2PTGS1ABCB11MT-CO2 | |
| SCHEMBL11435906 | 0.69 | CXCL8 (0.71) | CXCL8PTGS2TTRPTGS1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418200-A1 | PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES | EMS S. A. (BR) | 2012-02-15 | — | — | EP | disclosed |